生物节律紊乱与肿瘤发生的原由探秘

Exploration into circadian disruption and the cause of tumorigenesis

生物节律是维持生物体各项生理功能内稳态的重要保障,调控重要的日常生物过程和行为.近年来,由于外界环境变化和不良生活方式引起的机体生物节律紊乱已成为导致多种疾病的重要原因,其中节律紊乱与肿瘤发生发展具有密切关联.研究表明,生物节律紊乱通过打破机体的基因表达、代谢方式、免疫应答、神经内分泌和肠道菌群等方面的生理平衡而促进肿瘤的恶性进展,其中节律反馈机制的失调是打破生物节律"阴阳"平衡引起肿瘤恶化的普遍规律.因此,通过行为干预恢复生物体节律、抗肿瘤药物时间疗法的运用和靶向生物钟基因药物的开发已成为利用时间生物学治疗癌症的重要方向.综上,本文将系统性地总结节律紊乱与肿瘤调控之间的关系,并为时间生物学在肿瘤领域的应用提供新的研究视角和治疗策略.

Circadian rhythm sustains the homeostasis of systemic functions by regulating vital physiological processes and behaviors.Nowadays,circadian disruption caused by changing environments and deleterious lifestyles is responsible for many diseases.Cancer is facilitated by the circadian disruption that destroys the equilibrium of biological events,including gene expression,metabolic pathways,immune response,neuroendocrinology,and gut microbiota.The collapse of the circadian feedback mechanism is the underlying reason for the tilted balance of“Yin-Yang”to promote tumor development.Therefore,important chronobiological approaches have been applied to cancer treatment,such as restoring biological rhythms through behavioral intervention,using chronotherapy in antitumor drug administration,and developing drugs targeting clock genes.Conclusively,this paper will systematically review the relationship between circadian disturbances and tumor regulation and provide new research perspectives and treatment strategies for applying chronobiology in the field of cancer.