摘要
Gastric cancer(GC)is one of the most common malignant tumors worldwide.In China,GC is the second most common malignant tumor,and it is the second leading cause of cancer mortality.[1]Correa model showed that the development of intestinal-type GC was a consecutive cancerous process including normal gastric mucosa,non-atrophic gastritis,atrophic gastritis(AG),intestinal metaplasia(IM),dysplasia and intestinal-type GC in sequence.[2]Epithelium-resembling intestinal morphology replaced gastric mucosa which was defined as IM.[3]Among these precancerous conditions,IM was demonstrated to be a vital risk factor for GC,especially incomplete IM and extensive IM.[4,5].
基金
supported by grants from Shaanxi Foundation for Innovation Team of Science and Technology(No.2018TD-003)
Project from State Key Laboratory of Cancer Biology(No.CBSKL2019ZZ07)。