复方皂角刺膏治疗癌性疼痛的临床研究

Clinical study on the treatment of cancer pain with compound Chinese honeylocust spine ointment

目的探讨复方皂角刺膏治疗癌性疼痛的临床疗效及安全性。方法选取本院2020年1月1日至6月30日收治的癌性疼痛患者60例,按随机原则分为研究组和对照组,每组各30例。对照组根据患者癌性疼痛程度选择布洛芬缓释胶囊、盐酸曲马多缓释片、盐酸羟考酮缓释片治疗,观察组在此基础上加用复方皂角刺膏治疗,记录两组患者的疼痛强度、长效阿片类止痛药物使用情况、生活质量KRS评分及不良反应发生情况。结果用药后7 d研究组NRS评分明显低于对照组,差异有统计学意义(P<0.05)。两组患者用药后7 d的NRS评分明显低于用药前1 d和用药后1 d,差异有统计学意义(P<0.05),但研究组降低幅度更为明显。对照组用药后7 d的用药剂量与用药后1 d比较,差异无统计学意义(P>0.05);研究组用药后7 d的用药剂量明显低于用药后1 d,差异有统计学意义(P<0.05)。两组患者治疗前KPS评分比较,差异无统计学意义(P>0.05),两组在治疗完成后KPS评分比较,差异无统计学意义(P>0.05);两组患者治疗后的KPS评分均高于治疗前,差异有统计学意义(P<0.05)。研究组接受治疗后发生不良反应(包括恶心、呕吐,头晕、嗜睡)情况与对照组比较,差异无统计学意义(P>0.05),治疗后,研究组发生便秘例数低于对照组,但差异无统计学意义(P>0.05)。结论复方皂角刺膏治疗癌性疼痛效果明显,提高患者的生活质量,值得临床广泛推广。

Objective To investigate the clinical efficacy and safety on the treatment of cancer pain with compound Chinese honeylocust spine ointment.Methods A total of 60 patients with cancer pain admitted to our hospital from January 1 to June 30,2020 were selected,and they were divided into the study group(n=30)and the control group(n=30)according to random principle.Patients in the control group were treated with ibuprofen sustained-release capsules,tramadol hydrochloride sustained-release tablets and oxycodone hydrochloride sustained-release tablets according to the degree of cancer pain,while those in the observation group were treated with compound Chinese honeylocust spine ointment on the basis of the control group.Pain intensity,use of long-acting opioid analgesics,KRS score of quality of life(QoL)and adverse reactions(ADRs)of the two groups of patients were recorded.Results After 7 days of medication,NRS score of the study group was significantly lower than that of the control group,with statistically significant difference(P<0.05).The NRS scores of patients in the two groups after 7 days of medication were significantly lower than those at 1 day before medication and the first day after medication,with statistically significant difference(P<0.05),but the decrease in the study group was more remarkable.There was no statistically significant difference in the dosage of the control group after 7 days of medication compared with that after 1 day of medication(P>0.05).The dosage of the study group after 7 days of medication was significantly lower than that after 1 day of medication,with statistically significant difference(P<0.05).There was no statistically significant difference in KPS scores between two groups before treatment(P>0.05),and there was no statistically significant difference in KPS scores between two groups after treatment(P>0.05).The KPS score of two groups after treatment was higher than that before treatment,the difference was statistically significant(P<0.05).After treatment,there were no statistically significant differences in ADRs(including nausea,vomiting,dizziness and lethargy)between the study group and the control group(P>0.05).After treatment,the number of constipation cases in the study group was lower than that in the control group,without statistically significant difference(P>0.05).Conclusion Compound Chinese honeylocust spine ointment has remarkable analgesic effect on cancer pain,and it improves the QoL of patients.Therefore,it is worthy of widely clinical promotion.