基于基因多态性不同位点的检测结果对阿片类药物给药剂量的评价

Evaluation of opioid dosing based on the detection of different sites of genetic polymorphisms

大部分基因多态性对于阿片类镇痛药物使用剂量有一定程度的影响,从药物基因组学角度分析影响阿片类药物的镇痛作用,主要包括阿片样物质肽受体、效应分子、代谢酶和转运蛋白等影响因素的基因多态性,以及这些基因多态性带来的关于药物给药剂量以及不良反应发生的差异。系统性地研究影响阿片类镇痛药物使用剂量的各种基因的多态性,并进行合理分析与综合评价,才能最终得出精准、科学的治疗方案。

Most genetic polymorphisms have a certain impact on the dosage of opioid analgesics.From the perspective of pharmacogenomics,the analysis of the analgesic effects of opioids mainly includes the analysis of opioid peptide receptors,effector molecules,and metabolism.Gene polymorphisms of influencing factors such as enzymes and transporters and the differences in drug administration doses and adverse reactions caused by these genetic polymorphisms.Only by systematically studying the polymorphisms of various genes that affect the dosage of opioid analgesics and conducting rational analysis and comprehensive evaluation can we finally arrive at an accurate and scientific treatment plan.