维生素代谢组学在ARDS中应用的研究进展

Research progress of vitamin metabolomics in acute respiratory distress syndrome

急性呼吸窘迫综合征(ARDS)在临床具有发病率高、病死率高的特点,是导致重症患者死亡的重要因素之一。探索ARDS早期预警、严重程度及预后评估的生物学标志物(组)是研究的重点和难点。代谢紊乱与代谢支持在危重症救治中被日益重视,越来越多的研究表明维生素及其代谢产物变化可动态反映ARDS的损伤环节,并将为ARDS早期诊断、动态评估,乃至特异性治疗靶点筛选提供新的切入点。维生素代谢组学作为代谢组学的重要分支,有助于更好地寻找ARDS的潜在生物标志物。代谢组学是精准医学的最新技术手段,运用代谢组学方法分析维生素代谢产物及其途径在危重症诊治和监测中具有重要意义。本文对维生素代谢组学在ARDS中应用的相关研究进展进行综述。

Acute respiratory distress syndrome(ARDS)is a clinical syndrome with high morbidity and mortality in the field of critical care medicine.Exploring the biological markers(groups)for early warning,severity and prognosis assessment of ARDS is the critical points of recent research.Metabolic disorders and metabolic support are drawing more and more attention in the treatment of critically ill patients.Lots of studies have shown that the changes of vitamins and their metabolites can dynamically correspond to the damage of ARDS,which might be the biomarker for early diagnosis,dynamic evaluation,and specific treatment of ARDS.Vitamin metabolomics,as an important branch of metabolomics,can better help us find the potential biomarkers for ARDS.Metabolomics is the latest technology of precision medicine.The use of metabolomics to analyze vitamin metabolites and their pathways is of great significance in the diagnosis,treatment and monitoring of critical illnesses.This article reviews the research progress of vitamin metabolomics in ARDS.