氧化应激反应在流感病毒相关ARDS中作用的研究进展

Effect of oxidative stress response in acute respiratory distress syndrome caused by influenza

流感病毒是引起急性呼吸道传染病的常见病原体之一,感染人体后容易导致急性呼吸窘迫综合征(ARDS),是造成流感患者死亡的重要原因。流感病毒通过侵入人体的肺上皮细胞,引起机体广泛的炎症反应及免疫反应,造成组织损伤及细胞凋亡,从而诱导ARDS的发生发展。此外,流感病毒还可以引起机体强烈的氧化应激反应,产生大量活性氧,破坏肺上皮-内皮屏障,造成肺水肿。目前,多项研究已经表明,抗氧化剂对流感病毒感染具有抑制及治疗作用。因此,本文针对流感相关ARDS的流行病学、相关机制、氧化应激反应在流感相关ARDS发生发展中的作用以及抗氧化剂在抗流感病毒感染中的作用进行讨论,以期为有效控制流感患者病情、降低病死率、研发抗流感新药和防控流感流行提供参考。

Influenza virus is one of the common pathogens causing acute respiratory infectious diseases,and is easy to cause acute respiratory distress syndrome(ARDS)after infecting human body,which is an important cause of death of influenza patients.Influenza-induced ARDS results from a combination of overwhelming inflammation and immune response,causing tissue damage and apoptosis.Furthermore,virus-mediated oxidative stress is another important mechanism.Viral infection can produce excessive reactive oxygen species,which damage the epithelial-endothelial barrier with pulmonary edema.In this content,numerous studies have highlighted the importance of antioxidants as a new therapy aimed at blocking both viral replication and virus-induced inflammation.Therefore,this paper summarizes the epidemiology and mechanisms of influenza-induced ARDS,the role of oxidative stress in the occurrence and development of influenza-related ARDS and the role of antioxidants in anti influenza virus infection,in order to provide reference for effective treatment of influenza patients,reducing mortality,developing new anti influenza drugs and preventing and controlling influenza epidemic.