补肾导浊颗粒治疗慢性前列腺炎/慢性盆腔疼痛综合征的疗效及机制研究

Efficacy and mechanism of Bushen Daozhuo granules in the treatment of chronic prostatitis/chronic pelvic pain syndrome

目的探讨补肾导浊颗粒治疗慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)的疗效及机制。方法根据入选标准,搜集CP/CPPS患者160例,随机分成对照组和中药组各80例。对照组患者口服盐酸坦索罗辛缓释胶囊,0.2mg/次,每天1次;中药组服用补肾导浊颗粒治疗,200 ml/次,2次/日。两组分别在治疗前和治疗4周后统计慢性前列腺炎症状评分(CPSI)和疗效,检测前列腺液中细胞因子(TNF-α、IL-1β、IL-10)、血液流变学(HBV、MBV、LBV)和血清性激素(LH、FSH、T、E_(2))的水平。结果共有152例患者完成本研究,其中对照组75例,中药组77例。治疗4周后,对照组的排尿评分、生活质量评分和前列腺液中TNF-α、IL-1β、IL-10较治疗前均有显著改善(P<0.05);中药组的治愈率、显效率及总有效率均显著高于对照组,中药组CPSI各项评分、前列腺液中细胞因子、血液流变学指标和性激素(LH、T、E2)较治疗前有显著改善(P<0.05),且改善程度均优于对照组(P<0.05)。结论补肾导浊颗粒治疗CP/CPPS的疗效确切,其作用机制可能是通过调控全身性激素和血液流变学,改善前列腺内的炎性状态。

Objective To investigate the efficacy and mechanism of Bushen Daozhuo granules in the treatment of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS).Methods According to the selection criteria,160 patients with CP/CPPS were collected and randomly divided into the control group and Chinese Medicine group,80 cases each group.The patients in the control group were treated with oral tamsulosin hydrochloride sustained-release capsules,0.2 mg/time,once a day,and the patients in the Chinese Medicine group with Bushen Daozhuo granules,200 ml/time,twice a day.The chronic prostatitis symptom score(CPSI)and efficacy of the two groups were counted before treatment and 4 weeks after treatment,and their cytokines(TNF-α,IL-1β,IL-10),hemorheology(HBV,MBV,LBV),and serum sex hormones(LH,FSH,T,E_(2))levels were also measured.Results A total of 152 patients completed the study,including 75 in the control group and 77 in the Chinese Medicine group.After 4 weeks of treatment,the urination score,quality of life score,with TNF-α,IL-1β,and IL-10 in the prostate fluid of the control group were significantly improved compared with those before treatment(P<0.05).The cure rate,significant rate and total effective rate of the Chinese Medicine group were significantly higher than those of the control group.The CPSI scores,cytokines in the prostate fluid,blood rheology indexes and sex hormones(LH,T,E2)were significantly improved compared with those before treatment(P<0.05),and the degree of improvement was better than that of the control group(P<0.05).Conclusion Bushen Daozhuo granules is effective in treating CP/CPPS,and its mechanism may be to improve the inflammatory state in the prostate by regulating systemic hormones and hemorheology.