加味芍药汤治疗活动期溃疡性结肠炎疗效观察及对结肠病理改变的影响

Curative Observation of Modified Shaoyao Tang for Ulcerative Colitis in Active Stage and Its Effect on Pathological Changes of Colon

目的:观察加味芍药汤治疗活动期溃疡性结肠炎(UC)的疗效及对结肠病理改变的影响。方法:选择活动期UC患者50例,以简单随机化法分为对照组与治疗组各25例。对照组给予美沙拉嗪肠溶片治疗,治疗组在对照组基础上给予加味芍药汤治疗。治疗1个疗程后评估2组临床疗效,比较2组治疗前后中医证候积分、血清炎性因子水平、结肠镜检查及结肠组织病理改变情况。结果:治疗组总有效率96.00%,高于对照组76.00%(P<0.05)。与同组治疗前比较,2组治疗后中医证候积分、结肠镜检查评分、结肠组织病理改变评分及血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平均降低(P<0.05);与对照组治疗后比较,治疗组治疗后中医证候积分、结肠镜检查评分、结肠组织病理改变评分及血清IL-6、IL-8、TNF-α水平均较低(P<0.05)。结论:加味芍药汤治疗活动期UC疗效确切,可有效缓解患者临床症状,改善结肠镜检查结果及结肠组织病理表现,减轻炎症反应。

Objective:To observe the curative effect of modified Shaoyao tang for ulcerative colitis(UC)in active stage and its effect on pathological changes of colon.Methods:A total of 50 cases of UC patients in active stage were divided into the control group and the treatment group according to simple randomization method,with 25 cases in each group.The control group was treated with mesalazine enteric-coated tablets,and the treatment group was additionally treated with modified Shaoyao tang based on the treatment of the control group.After one course of treatment,the clinical effects in the two groups were evaluated.Before and after treatment,Chinese medicine syndrome scores,levels of inflammatory factors in serum,colonoscopy and pathological changes of colon in the two groups were compared.Results:The total effective rate was 96.00%in the treatment group,higher than that of 76.00%in the control group(P<0.05).After treatment,scores of Chinese medicine syndromes,colonoscopy and pathological changes of colon as well as levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in serum in the two groups were decreased when compared with those before treatment(P<0.05);scores of Chinese medicine syndromes,colonoscopy and pathological changes of colon as well as levels of IL-6,IL-8 and TNF-αin serum in the treatment group were lower than those in the control group(P<0.05).Conclusion:Modified Shaoyao tang has a definite curative effect in treating UC in active stage,which can effectively relieve clinical symptoms,improve colonoscopy results and pathological characteristics of colon,and relieve inflammatory responses.