益气固本汤对腹腔镜下结直肠癌根治术后化疗患者免疫功能及生活质量的影响

Effect of Yiqi Guben Tang on Immune Function and Quality of Life in Patients Under⁃going Chemotherapy After Laparoscopic Radical Resection of Colorectal Cancer

目的:观察益气固本汤对腹腔镜下结直肠癌根治术后化疗患者免疫功能及生活质量的影响。方法:选择68例行结直肠癌根治术后化疗的患者进行前瞻性研究,根据随机数字表法将纳入研究的病例分为研究组与对照组各34例。所有患者术后接受改良奥沙利铂^(+)氟尿嘧啶^(+)亚叶酸(FOLFOX6)化疗方案,研究组在此基础上加服益气固本汤。比较2组治疗前后静脉血中CD3^(+)、CD4^(+)、CD8^(+)含量,CD4^(+)/CD8^(+)比值,Karnofsky量表(KPS)评分及欧洲癌症研究治疗组开发的癌症患者生命测定量表-C30(EORTC QLQ-C30)评分;比较2组治疗后骨髓抑制程度。结果:与同组治疗前比较,治疗后对照组CD3^(+)、CD4^(+)含量及CD4^(+)/CD8^(+)降低(P<0.05),CD8^(+)含量升高(P<0.05),研究组CD3^(+)、CD4^(+)含量及CD4^(+)/CD8^(+)升高(P<0.05),CD8^(+)含量降低(P<0.05);与对照组治疗后比较,研究组治疗后CD3^(+)、CD4^(+)含量及CD4^(+)/CD8^(+)较高(P<0.05),CD8^(+)含量较低(P<0.05)。研究组治疗后骨髓抑制程度为Ⅲ、Ⅳ级的例数明显少于对照组(P<0.05)。与同组治疗前比较,治疗后2组KPS评分升高(P<0.05),EORTC QLQ-C30评分降低(P<0.05);与对照组治疗后比较,研究组治疗后KPS评分较高(P<0.05),EORTC QLQC30评分较低(P<0.05)。结论:益气固本汤对腹腔镜下结直肠癌根治术后化疗患者免疫功能改善疗效较好,可有效缓解患者骨髓抑制程度,提高患者生活质量。

Objective:To observe the effect of Yiqi Guben tang on immune function and quality of life in patients undergoing chemotherapy after laparoscopic radical resection of colorectal cancer.Methods:A total of 68 cases of patients undergoing chemotherapy after radical resection of colorectal cancer were selected for prospective study,and were divided into the study group and the control group according to the random number table method,with 34 cases in each group.After operation,both groups were given modified chemotherapy with oxaliplatin,fluorouracil and folic acid(FOLFOX6),and the study group was additionally treated with Yiqi Guben tang.The contents of CD3^(+),CD4^(+)and CD8^(+)in venous blood,the ratio of CD4^(+)to CD8^(+)and the scores of Karnofsky Scale(KPS)and Quality of Life Questionnaire in European Organization for Research and Treatment of Cancer-C30(EORTC QLQ-C30)before and after treatment as well as the degree of bone marrow suppression after treatment in the two groups were compared.Results:After treatment,the contents of CD3^(+)and CD4^(+)and CD4^(+)/CD8^(+)in the control group were decreased when compared with those before treatment(P<0.05),and the content of CD8^(+)was increased(P<0.05);the contents of CD3^(+)and CD4^(+)and CD4^(+)/CD8^(+)in the study group were increased(P<0.05),and the content of CD8^(+)was decreased(P<0.05);the contents of CD3^(+)and CD4^(+)and CD4^(+)/CD8^(+)in the study group were higher than those in the control group(P<0.05),and the content of CD8^(+)was lower(P<0.05).After treatment,the number of cases with grade Ⅲ and Ⅳ bone marrow suppression in the study group was significantly smaller than that in the control group(P<0.05).After treatment,KPS scores in the two groups were increased when compared with those before treatment(P<0.05),and EORTC QLQ-C30 scores were decreased(P<0.05);the KPS score in the study group was higher than that in the control group(P<0.05),and the EORTC QLQ-C30 score was lower(P<0.05).Conclusion:Yiqi Guben tang has a good curative effect on improving immune function of patients undergoing chemotherapy after laparoscopic radical resection of colorectal cancer,which can effectively relieve the degree of bone marrow suppression and improve the quality of life of patients.