GATA-6、Dkk-1及bFGF在垂体腺瘤中的表达及与预后的相关性

Expressions of GATA-6,Dkk-1 and bFGF in Pituitary Adenoma and Their Correlations with Prognosis

目的分析GATA结合蛋白-6(GATA-6)、Dickkopf相关蛋白-1(Dkk-1)及碱性成纤维生长因子(bFGF)在垂体腺瘤中的表达及与预后的相关性。方法选取2015年2月—2018年3月本院收治的经手术治疗的垂体腺瘤103例,收集其手术切除瘤组织及瘤旁正常组织,对比不同组织GATA-6、Dkk-1及bFGF表达情况,根据随访生存情况,采用多因素Logistic回归分析探讨影响垂体腺瘤患者预后的因素。结果103例瘤组织GATA-6及bFGF阳性表达率高于瘤旁正常组织,Dkk-1阳性表达率低于瘤旁正常组织,差异有统计学意义(P<0.01)。103例随访生存75例,死亡28例,生存率为72.82%。瘤卒中及GATA-6阳性、Dkk-1阴性、bFGF阳性表达是垂体腺瘤患者预后的独立危险因素(P<0.01)。结论GATA-6、bFGF在垂体腺瘤中高表达,Dkk-1在垂体腺瘤中低表达;GATA-6、Dkk-1及bFGF的异常表达是垂体腺瘤患者预后的独立危险因素。

Objective To analyze expressions of GATA binding protein 6(GATA-6),Dickkopf associated protein-1(Dkk-1)and basic fibroblast growth factor(bFGF)in pituitary adenomas and their correlations with prognosis.Methods A total of 103 patients with pituitary adenomas treated surgically between February 2015 and March 2018 were selected.The surgically removed cancer tissues and adjacent normal tissues were collected,and expressions of GATA-6,Dkk-1 and bFGF in different tissues were compared.According to survival conditions of patients during follow-up,multivariate Logistic regression analysis was used to analyze factors affecting prognoses of patients with pituitary adenomas.Results Compared with those in adjacent normal tissues,the positive expression rates of GATA-6 and bFGF were significantly higher,while the positive expression rate of Dkk-1 was significantly lower in 103 cancer tissues(P<0.01).Among the 103 patients with pituitary adenomas,75 patients had survived,and 28 patients had died during the follow-up period,and the survival rate was 72.82%.Oncological stroke,GATA-6 positive expression,Dkk-1 negative expression and bFGF positive expression were independent risk factors for prognoses of patients with pituitary adenomas(P<0.01).Conclusion GATA-6 and bFGF are highly expressed,and Dkk-1 is poorly expressed in pituitary adenomas.The abnormal expressions of GATA-6,Dkk-1 and bFGF are independent risk factors for the prognoses of patients with pituitary adenoma.