豨莶通栓胶囊联合长春西汀治疗脑梗死恢复期的疗效观察

Observation study on Xixian Tongshuan Capsules combined with vinpocetine in treatment of convalescence of cerebral infarction

目的观察豨莶通栓胶囊联合长春西汀片治疗脑梗死恢复期的临床疗效。方法选取2019年3月—2021年2月开封市中心医院收治的150例脑梗死恢复期患者,采用随机数字表法将患者分为对照组和治疗组,每组各75例。对照组饭后0.5 h口服长春西汀片,1片/次,3次/d。治疗组在对照组基础上饭后0.5 h口服豨莶通栓胶囊,3粒/次,3次/d。两组患者均连续治疗3个月。观察两组疗效,比较两组患者神经功能缺损情况、日常生活活动能力、脑血流动力学参数、血液流变学。结果治疗后,治疗组的总有效率为90.67%,高于对照组的总有效率74.67%,差异有统计学意义(P<0.05)。治疗后,两组美国国立卫生研究院脑卒中量(NIHSS)评分较治疗前降低,Barthel指数较治疗前升高(P<0.05),且治疗组的NIHSS评分、Barthel指数改善效果更明显(P<0.05)。治疗后,两组阻力指数(RI)、搏动指数(PI)较治疗前降低,平均血流速度(Vm)较治疗前升高(P<0.05),且治疗组的脑血流动力学参数改善效果更明显(P<0.05)。治疗后,两组纤维蛋白原、血浆比黏度、D-二聚体较治疗前降低(P<0.05),治疗组的纤维蛋白原、血浆比黏度、D-二聚体均明显低于对照组(P<0.05)。结论豨莶通栓胶囊联合长春西汀片治疗脑梗死恢复期的疗效较好,可提高患者日常生活能力,减轻脑神经功能缺损,进一步改善脑血流动力学参数和血液流变学,具有一定的临床应用价值。

Objective To observe the clinical effect of Xixian Tongshuan Capsules combined with Vinpocetine Tablets in treatment of convalescence of cerebral infarction. Methods Patients(150 cases) with convalescence of cerebral infarction in Kaifeng Central Hospital from March 2019 to February 2021 were randomly divided into control and treatment groups, and each group had 75 cases.Patients in the control group were po administered with Vinpocetine Tablets at half an hour after dinner, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Xixian Tongshuan Capsules at half an hour after dinner on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and the neurological deficit, activities of daily living, cerebral hemodynamic parameters, hemorheology in two groups were compared. Results After treatment, the total effective rate of the treatment group was 90.67%, which was higher than that of the control group(74.67%), and the difference was statistically significant(P < 0.05). After treatment, the NIHSS score and Barthel index in two groups were lower than those before treatment(P < 0.05), and the NIHSS score and Barthel index in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, RI and PI in two groups were lower than before treatment, but the Vm in two groups was higher than before treatment(P < 0.05), and the improvement of cerebral hemodynamic parameters in treatment group was more significant(P < 0.05). After treatment, the fibrinogen, plasma specific viscosity,and D-dimer in two groups were lower than those before treatment(P < 0.05), and the fibrinogen, plasma specific viscosity, and Ddimer in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Xixian Tongshuan Capsules combined with Vinpocetine Tablets has clinical curative effect in treatment of convalescence of cerebral infarction, can improve the ability of daily living, reduce the defect of cerebral nerve function, and further improve the parameters of cerebral hemodynamics and hemorheology, which has a certain clinical value.