多糖铁复合物胶囊治疗妊娠期缺铁性贫血的疗效观察

Clinical observation of Iron Polysaccharide Complex Capsules in treatment of iron deficiency anemia during pregnancy

目的探究多糖铁复合物胶囊治疗孕妇妊娠期缺铁性贫血的临床疗效。方法选取2018年4月—2020年11月天津医科大学总医院滨海医院收治的352例缺铁性贫血孕妇,所有患者按照随机数表法分为对照组和治疗组,每组各176例。对照组口服琥珀酸亚铁片,2片/次,3次/d。治疗组口服多糖铁复合物胶囊,2粒/次,1次/d。两组均连续治疗4周。观察两组的临床疗效,比较两组治疗前后的血常规指标、铁代谢相关指标以及两组孕妇妊娠结局、不良反应发生情况。结果治疗后,治疗组的总有效率(95.45%)显著高于对照组(87.50%)(P<0.05)。治疗后,两组红细胞计数(RBC)、红细胞压积(HCT)、血红蛋白(Hb)均显著提高(P<0.05);且治疗组RBC、HCT、Hb显著高于对照组(P<0.05)。治疗后,两组血清铁(SI)、血清铁蛋白(SF)均显著提高(P<0.05);且治疗组SI、SF显著高于对照组(P<0.05)。治疗后,治疗组不良妊娠结局发生率(14.20%)显著低于对照组(22.73%)(P<0.05)。治疗期间,治疗组不良反应发生率(5.11%)显著低于对照组(12.50%)(P<0.05)。结论多糖铁复合物胶囊治疗妊娠期缺铁性贫血疗效显著,可明显改善孕妇血常规指标,改善母婴结局,安全性较好。

Objective To investigate the effect of Iron Polysaccharide Complex Capsules in treatment of iron deficiency anemia during pregnancy.Methods Pregnant woman(352 cases)with iron deficiency anemia in Binhai Hospitial of General Hospital Affiliated to Tianjin Medical University from April 2018 to November 2020 were randomly divided into control and treatment groups,and each group had 176 cases.Patients in the control group were po administered with Ferrous Succinate Tablets,2 tablets/time,three times daily.Patients in the treatment group were po administered with Iron Polysaccharide Complex Capsules on the basis of the control group,2 grains/time,once daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies were evaluated,and the blood routine indexes,the related indexes of iron metabolism,the pregnancy outcomes,and the adverse reactions in two groups were compared.Results After treatment,the total effective rate of the treatment group(95.45%)was significantly higher than that of the control group(87.50%)(P<0.05).After treatment,the RBC,HCT,and Hb in two groups were significantly increased(P<0.05).After treatment,the RBC,HCT,and Hb in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,the SI and SF in two groups were significantly increased(P<0.05),and the SI and SF in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,the incidence of adverse pregnancy outcomes in the treatment group(14.20%)was significantly lower than that in the control group(22.73%)(P<0.05).During the treatment period,the incidence of adverse reactions in the treatment group(5.11%)was significantly lower than that in the control group(12.50%)(P<0.05).Conclusion Iron Polysaccharide Complex Capsules has clinical curative effect in treatment of iron deficiency anemia during pregnancy,can improve the blood routine indexes,and improve the maternal and infant outcomes,with good safety.