阿戈美拉汀联合乙哌立松治疗青年慢性紧张性头痛的疗效分析

Efficacy and Safety of Agomelatine Combined with Eperisone in the Treatment of Chronic Tension-type Headache(CTTH) in Youth

目的探讨阿戈美拉汀联合乙哌立松治疗青年慢性紧张性头痛(Chronictention-typeheadache,CTTH)的疗效及安全性。方法 80例青年慢性紧张性头痛患者依据是否倒班随机分为对照组和治疗组,对照组口服乙哌立松治疗,治疗组在对照组基础上联合阿戈美拉汀治疗,评估2组患者治疗前匹兹堡睡眠量表评分(PSQI)评估治疗6周后两组的头痛疗效以及不良反应。结果倒班人员的入组前PSQI的总评分、睡眠质量、入睡时间、催眠药物及睡眠障碍因子分高于非倒班人员;治疗组的疗效优于对照组,有统计学意义(P<0.05);治疗组内,倒班患者疗效优于非倒班患者(P<0.05)。两组不良反应无明显差异。结论阿戈美拉汀联合乙哌立松治疗慢性紧张性头痛的的疗效确切,安全性高。

Objective This study aims to investigate the efficacy and safety of agomelatine combined with eperisone in the treatment of chronic tension-type headache(CTTH)in youth. Methods 80 youth individuals with CTTH were divided into two groups according to whether on shift or not :the control group was treated with eperisone,the treatment group was treated with argonaut on the basis of the control treatment. Both of the two groups were evaluated by Pittsburgh sleep rating scale(PSQI)before treatment. The treatments was lasted for 6 weeks,then the clinical efficacy and adverse reactions was compared. Results There were significantly higher PSQI factors scores of the patients with shift work than those with non-shift work,including the total score of PSQI、sleep quality、time to fall asleep、hypnotic drugs and sleep disorder factor scores. There was a better therapeutic effect of the treatment group,with statistical significance(P<0.05). Within the treatment group,the efficacy of shift patients was better than that of non-shift patients(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Agomelatine is effective and safe in the treatment of chronic tension headache. Agomelatine had a significant effect on CTTH patients in the shift group.