黄葵胶囊联合阿卡波糖治疗糖尿病肾病临床研究

Clinical Study of Huangkui Capsules Combined with Acarbose for Diabetic Nephropathy

目的:观察黄葵胶囊联合阿卡波糖治疗糖尿病肾病的临床疗效及其对糖代谢、肾纤维化的影响。方法:将189例糖尿病肾病患者按随机数字表法分为研究组95例和对照组94例。所有患者均接受相同的基础治疗并控制血压,对照组给予口服阿卡波糖治疗,研究组在对照组的基础上加用黄葵胶囊治疗。2组均连续治疗8周,分析比较2组临床疗效,检测2组患者治疗前后空腹血糖值(FBG)、餐后2 h血糖值(P2hBG)和糖化血红蛋白(HbA1c)等糖代谢指标水平,血肌酐(SCr)、血尿酸(UA)、血尿素氮(BUN)等肾功能指标水平,血清转化生长因子-β1(TGF-β1)、基质金属蛋白酶抑制剂-1(TIMP-1)等肾纤维化指标水平。结果:治疗后,研究组临床疗效优于对照组,经秩和检验,差异有统计学意义(P<0.05)。治疗前,2组FBG、P2hBG、HbA1c、SCr、UA、BUN、TGF-β1、TIMP-1水平比较,差异无统计学意义(P>0.05);治疗后,2组上述指标均较治疗前降低(P<0.05),且研究组各项指标均低于对照组(P<0.05)。结论:黄葵胶囊联合阿卡波糖对糖尿病肾病患者疗效肯定,可改善患者糖代谢及肾功能,有效下调肾脏纤维化指标。

Objective:To observe the clinical effect of Huangkui capsules combined with acarbose for diabetic nephropathy and its effect on sucrose metabolism and renal fibrosis.Methods:A total of 189 cases of patients with diabetic nephropathy were divided into the study group and the control group according to the random number table method,with 95 cases and 94 cases in each group respectively.All patients received the same basic treatment and their blood pressure were controlled.The control group was additionally treated with oral administration of acarbose,and the study group was additionally treated with Huangkui capsules based on the treatment of the control group.Both groups were treated for eight weeks.The clinical effects in the two groups were analyzed and compared.Before and after treatment,the levels of indexes of sucrose metabolism,such as fasting blood glucose(FBG),2-h postprandial blood glucose(P2hBG)and glycosylated hemoglobin A1c(HbA1c),indexes of the kidney function such as serum creatinine(SCr),serum uric acid(UA)and blood urea nitrogen(BUN),as well as indexes of renal fibrosis such as serum transforming growth factor-β1(TGF-β1)and tissue inhibitor of metalloproteinases-1(TIMP-1)were detected.Results:After treatment,the clinical effect in the study group was better than that in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of FBG,P2hBG,HbA1c,SCr,UA,BUN,TGF-β1 and TIMP-1 between the two groups(P>0.05);after treatment,the above levels in both groups were decreased when compared with those before treatment(P<0.05),and the above levels in the study group were lower than those in the control group(P<0.05).Conclusion:Huangkui capsules combined with acarbose has a definite effect on patients with diabetic nephropathy,which can effectively reduce renal fibrosis indexes as well as improve glucose metabolism and the kidney function.