内镜介入治疗急性梗阻性黄疸的疗效及对患者炎症因子的影响

Efficacy of Endoscopic Interventional Treatment of Acute Obstructive Jaundice and Its Influence on Patients'Inflammatory Factors

目的探究内镜介入治疗急性梗阻性黄疸的疗效及对患者炎症因子的影响。方法方便选择2019年12月—2020年12月福建医科大学附属福州市第一医院消化内科收治的75例急性梗阻性黄疸患者作为该次研究的观察对象,均给予经内镜逆行胰胆管造影(ERCP)置入支架进行介入治疗,比较患者治疗前和治疗后的血清总胆红素(TBIL)、血清总胆汁酸(TBA)、碱性磷酸酶(ALP)、y-谷氨酰转肽酶(y-GT)、谷丙转氨酶(GPT)、C反应蛋白(CRP)和白介素-6(IL-6)的水平,观察患者的住院时间、术后并发症的发生情况和临床治疗总有效率。结果经治疗后,患者TBIL的水平为(75.39±9.12)μmol/L、TBA的水平为(22.75±2.22)μmol/L,均低于治疗前(235.57±17.90)、(82.75±10.07)μmol/L,差异有统计学意义(t=39.867、29.093,P<0.05);ALP、y-GT、GPT、CRP和IL-6的水平均低于治疗前,差异有统计学意义(P<0.05);经治疗后,患者的住院时间为(5.62±0.74)d,术后并发症总发生率较低,临床治疗总有效率较高。结论内镜介入治疗急性梗阻性黄疸能有效改善患者的肝功能和黄染程度,抑制其体内的炎症因子,治疗安全性较高,患者的住院时间较短,术后并发症发生率较低,临床疗效显著,值得推荐。

Objective To explore the efficacy of endoscopic interventional treatment of acute obstructive jaundice and its influence on patients with inflammatory factors.Methods Conveniently selected 75 patients with acute obstructive jaundice admitted to the Department of Gastroenterology,Fuzhou First Hospital Affiliated to Fujian Medical University from December 2019 to December 2020,were selected as the observation objects of this study,and they were all given endoscopic retrograde pancreas.Cholangiography(ERCP)was implanted with a stent for interventional therapy.The serum total bilirubin(TBIL),serum total bile acid(TBA),alkaline phosphatase(ALP),and y-glutamyl Transpeptidase(y-GT),alanine aminotransferase(GPT),C-reactive protein(CRP)and interleukin-6(IL-6)levels were compared before and after treatment,observe the patient's hospital stay,postoperative complications and clinical treatment efficiency.Results After treatment,the patient's TBIL level was(75.39±9.12)μmol/L,and the TBA level was(22.75±2.22)μmol/L,both lower than before treatment(235.57±17.90)μmol/L(82.75±10.07)μmol/L,the difference was statistically significant(t=39.867,29.093,P<0.05);the levels of ALP,y-GT,GPT,CRP and IL-6 were lower than before treatment,the difference was statistically significant(P<0.05);after treatment,the patient of the length of hospital stay was(5.62±0.74)d,the total incidence of postoperative complications was low,and the total effective rate of clinical treatment was higher.Conclusion Endoscopic interventional treatment of acute obstructive jaundice can effectively improve the liver function and the degree of yellow staining,inhibit the inflammatory factors in the body,and have high treatment safety.The patient's hospital stay is shorter,the incidence of postoperative complications is low,and the clinical effect is significantly and highly recommended.