炎症性肠病患者急性胰腺炎发生风险的Meta分析

Meta-analysis of the Risk of Acute Pancreatitis in Patients with Inflammatory Bowel Disease

目的在炎症性肠病(inflammatory bowel disease,IBD)患者中,急性胰腺炎(acute pancreatitis,AP)的发生风险存在争议,通过病例对照研究和观察性研究的荟萃分析,研究IBD与急性胰腺炎发生风险间的相关性。方法计算机检索PubMed、MEDLINE、EMBASE、CNKI及万方数据库系统,查找IBD患者中AP发生率的相关文献。由两名研究者独立完成文献的纳入与排除、质量评价及数据提取,应用Cochrane协作网提供的Review Manager 5.4分析软件对数据进行统计分析。结果共纳入6篇文献,荟萃分析结果显示,在IBD人群中AP的发生率显著升高(OR=1.51,95%CI:1.43~1.60,P<0.001),其中Crohn病(Crohn disease,CD)组患者AP的发生率更高(Crohn患者群:OR=4.13,95%CI:3.75~4.54,P<0.001;溃疡性结肠炎患者群:OR=2.60,95%CI:2.39~2.82,P<0.001)。结论IBD患者AP的风险增加,其中CD患者该风险更高。

Objective In patients with inflammatory bowel disease(IBD),the risk of acute pancreatitis(Acute pancreatitis,AP)is controversial.A meta-analysis of case-control studies and observational studies is used to study the relationship between IBD and acute pancreas.The correlation between the risk of inflammation was studied.Methods Computer searched PubMed,MEDLINE,EMBASE,CNKI and Wanfang database systems to find relevant literature on the incidence of AP in IBD patients.Two researchers independently completed the inclusion and exclusion,quality evaluation and data extraction of the literature,and used the Review Manager 5.4 analysis software provided by the Cochrane Collaboration to perform statistical analysis on the data.Results A total of 6 articles were included.The meta-analysis results showed that the incidence of AP in the IBD population was significantly increased(OR=1.51,95%CI:1.43-1.60,P<0.001),among which Crohn disease(CD),the incidence of AP in the group was higher(Crohn disease population:OR=4.13,95%CI:3.75~4.54,P<0.001;ulcerative colitis disease population:OR=2.60,95%CI:2.39-2.82,P<0.001).Conclusion IBD patients have an increased risk of AP,and CD patients have a higher risk.