并行微通道中流体的连续输运与流量控制研究

Research on continuous fluid transport and flow control in parallel microchannels

微流体精确地、连续地输运,以及并行多通道中每个微通道的微流体流量均一性,是实现微流控技术量产制备功能微球必须解决的问题。文中通过改变齿轮泵入口管内径、并行微通道出口管内径以及流体黏度,进行齿轮泵输出流量和多通道中微流体流量均分的控制。研究结果表明:通过减小齿轮泵入口管内径和微通道内径以及增大流体的黏度,使得商业化齿轮泵的高泵输流量减小至微流控技术中需求的流体泵输量,解决了微流体的精确连续输运问题。此外,流体流量变异系数CV随着齿轮泵入口管内径的增大、微通道内径的减小以及流体黏度的增大而减小,通过这些参数的合理选择可以实现微通道中流体流量的均一性控制。研究获得CV值与其影响因素之间的经验公式。

To realize the mass production of functional microspheres by microfluidic technology,problems of precise and continuous microfluidic transport and uniform microfluidic flow rate of each microchannel in parallel multi-channel must be solved.The output flow and the flow distribution of the microfluid in multi-microchannel were controlled by changing the inner diameter of the inlet pipe,the diameter of the parallel outlet pipe and the viscosity of the fluid.The results show that by reducing the inner diameter of the inlet pipe of the gear pump and the size of the microchannel,or increasing the viscosity of the fluid,the pumping flow rate of the commercial gear pump is reduced to the required flow rate of the fluid pump in the microfluidic technology,and the problem of accurate and continuous transport of the microfluidic is solved.Besides,the coefficient of variation CV of fluid flow decreases with the increase of the inner diameter of the inlet pipe of gear pump,the decrease of the inner diameter of microchannel and the increase of fluid viscosity.The empirical formula describing the relationship between CV value and its influencing factors is obtained.