摘要
非酒精性脂肪性肝病相关肝细胞癌发病率在世界范围内呈增长趋势,然而其发病机制仍不明确。结合近年文献,总结脂肪组织炎症、氧化应激、肠道菌群及胰岛素抵抗在非酒精性脂肪性肝病相关肝细胞癌发病过程中的作用,并针对以上机制的防治进展进行综述,为其治疗提供新思路。
The incidence rate of nonalcoholic fatty liver disease-related hepatocellular carcinoma(NAFLD-HCC)tends to increase worldwide,while its pathogenesis remains unclear.With reference to the literature in recent years,this article summarizes the role of adipose tissue inflammation,oxidative stress,gut microbiota,and insulin resistance in the pathogenesis of NAFLD-HCC and the advances in the prevention and treatment of the above mechanisms,so as to provide new ideas for the treatment of NAFLD-HCC.
作者
辜雪莲
李俊峰
毛小荣
GU Xuelian;LI Junfeng;MAO Xiaorong(The First Clinical Medical School of Lanzhou University,Lanzhou 730000,China;Department of Infectious Diseases,The First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第1期196-200,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金(81800528)
甘肃省自然科学基金(20JR5RA364)
甘肃省重点研发计划(20YF2FA011)
甘肃省卫生行业科研计划项目(GSWSKY2018-24)。
关键词
非酒精性脂肪性肝病
癌
肝细胞
氧化性应激
Non-alcoholic Fatty Liver Disease
Carcinoma,Hepatocellular
Oxidative Stress
