瞬时感受器电位离子通道蛋白V4在肝脏疾病中的作用机制

Research advances in the mechanism of action of TRPV4 ion channel protein in liver diseases

瞬时感受器电位离子通道蛋白V4(TRPV4)属于瞬时感受器电位离子通道家族中的一员,是一种非选择性阳离子通道,其广泛分布在多种组织及器官中。近年来越来越多的研究介绍了TRPV4通道蛋白与肝纤维化、肝癌、多囊性肝病等肝脏疾病的密切关系。本文主要对TRPV4与肝脏疾病的有关文献进行分析,归纳总结TRPV4与肝脏疾病之间确切的信号通路及可能的潜在机制,以期临床应用及进一步研究。

As a member of the transient receptor potential ion channel family,transient receptor potential vanilloid 4(TRPV4)is a non-selective cation channel and is widely distributed in a variety of tissues and organs.In recent years,more and more studies have shown that TRPV4 channel proteins are closely associated with liver diseases such as liver fibrosis,liver cancer,and polycystic liver disease.This article analyzes the articles on TRPV4 and liver disease and summarizes the exact signaling pathways and possible potential mechanism between TRPV4 and liver disease,so as to provide new ideas for clinical application and further studies.