丽江玛咖和秘鲁玛咖功效和安全性对比研究

Comparative Research on Efficacy and Safety of Maca(Lepidium meyenii Walp.)from Lijiang and Peru

采用小鼠负重游泳试验、小鼠肝糖原和血清尿素氮测定,评价丽江玛咖和秘鲁玛咖的缓解体力疲劳作用;采用小鼠交配试验、小鼠精子数量、精子活率和性腺器官指数检测,比较丽江玛咖和秘鲁玛咖的改善性功能作用方面的活性差异;采用小鼠急性毒性试验初步评价丽江玛咖和秘鲁玛咖的安全性。结果表明:与空白组比较,丽江玛咖和秘鲁玛咖均可明显提升小鼠负重游泳时间和肝组织糖原水平,显著降低小鼠血清尿素氮水平;与空白组比较,丽江玛咖和秘鲁玛咖均可显著提升小鼠交配能力、精子数量和睾丸指数,但对小鼠精子活率、精囊和包皮腺指数均无明显影响。与秘鲁玛咖组比较,丽江玛咖在缓解体力疲劳和改善性功能方面的活性无明显差异。急性毒性试验结果显示,丽江玛咖和秘鲁玛咖的最大给药量为17.48 g/kg,给药后均未见明显毒性反应和死亡。

The weight-loading swimming assay, liver glycogen and serum urea nitrogen tests in mice were used to evaluate the alleviating physical fatigue effects of Lijiang and Peru Maca. The mouse mating assay,sperm quantity, survival rate and gonadal organ index tests were used to observe the improving sexual function between them. The acute toxicity test was used to evaluate the safety of two samples. The result showed that compared with the blank control group, Lijiang and Peru Maca can significantly increase the swimming time and the level of liver glycogen, as well as reduce the level of urea nitrogen in mice.Compared with the blank control group, Lijiang and Peru Maca can obviously improve the mating ability, sperm quantity and testis index in mice, but it has no obvious effect on sperm viability, seminal vesicles and Foreskin gland index. Compared with the Peru Maca group, there was no significant difference in the activity of anti-fatigue and improving sexual function. The acute toxicity test showed that the maximum dose of Lijiang and Peru Maca was 17.48 g/kg. There was no toxicity or death after administration.