多原发肺癌诊断的分子生物学检测

Study of molecular biological detection in diagnosis of multiple primary lung cancer

多原发肺癌(MPLC)在肺癌中相对少见。近年来随着人们对体检的重视以及影像学特别是高分辨率CT和PET/CT技术的发展, 越来越多的患者被诊断出多发性肺癌, 而区分多发性肺癌究竟是MPLC还是肺内转移显得尤为重要, 因为这直接关系到肿瘤的分期以及后续治疗的选择。本文根据现有文献对分子生物学检测在MPLC诊断上的研究进展进行综述, 旨在进一步加深对MPLC的认识, 提高MPLC的诊断水平。

Multiple primary lung cancer(MPLC)is relatively rare in lung cancer.In recent years,multiple lung cancers are diagnosed in rising number patients with paying regard to physical examination,and the development of imaging especially high-resolution CT and PET/CT.However differentiating MPLC or intrapulmonary metastasis of multiple lung cancers becomes very important due to the result is directly related to both tumor staging and the follow-up treatment.This review article describes the research progress of molecular biology detection in diagnosis of MPLC according to current literature,aiming to further deepen the understanding of MPLC and improve the diagnostic level of MPLC.