中性粒细胞外诱捕网和重症新型冠状病毒肺炎关系的研究进展

Advances in relationship between neutrophil extracellular traps and severe COVID-19

新型冠状病毒肺炎(COVID-19)是由严重急性呼吸综合征冠状病毒2感染导致的传染性较强的急性呼吸道疾病。该病临床表现轻重不一, 轻症可仅表现为轻度的上呼吸道感染的症状, 严重者可蔓延至下呼吸道, 甚至出现危及生命的并发症, 如急性呼吸窘迫综合征、败血症性休克、多脏器衰竭等。目前, COVID-19发病机制尚不十分明确, 但是有病理研究显示在COVID-19患者肺、肾、肝组织中有大量的中性粒细胞外诱捕网(NETs), 因此猜测NETs可能参与到COVID-19的病情进展中。本文就NETs在重症COVID-19中的研究进展作一综述。

Coronavirus disease 2019(COVID-19)is a highly contagious acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The clinical manifestations of the disease are different.Mild disease severity manifests as upper respiratory tract infection,and severe disease severity likely extend to the lower respiratory tract infection,and the most serious immediate life-threatening complication,including acute respiratory distress syndrome(ARDS),septic shock,and multiple organ failure.At present,Etiology and pathogenesis of COVID-19 is unclear,but the pathological studies indicate that there are a large number of neutrophil extracellular traps(NETs)in lung,kidney and liver tissues of COVID-19 patients.Therefore,it further speculates that NETs are capable of involvement in progression of COVID-19.This paper is a brief review of the advances in research into NETs in severe COVID-19.