1022例儿童感染沙门菌的流行特征及耐药分析

Epidemiological characteristics and drug resistance analysis of Salmonella infection in 1022 children

了解广州市妇女儿童医疗中心临床分离沙门菌的流行特征及耐药率。回顾分析1022例在我院临床分离的沙门菌,均进行血清学分型及药敏试验。研究表明,1022例沙门菌主要来源于粪便和血液;以3岁以下婴、幼儿组为主;季节分布呈夏、秋季高发;共检测到45种血清型,以鼠伤寒沙门菌检出率最高(80.0%)。药敏结果显示,沙门菌对氨苄西林耐药率最高(85.9%),对哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、环丙沙星的耐药率较低。粪便分离株对所检测抗菌药物的耐药率均高于血液分离株。多重耐药(MDR)沙门菌五年平均检出率8.9%,其中鼠伤寒沙门菌MDR率最低(6.8%)。儿童抗菌药物治疗要结合血清型及药敏结果慎重选择。

To investigate the epidemiological characteristics and drug resistance rates of clinically isolated Salmonella in Guangzhou Women and Children's Medical Center.A retrospective analysis was performed for 1022 cases of isolated clinically Salmonella in our hospital.All strains were subjected to serological typing and drug susceptibility tests.The findings showed that 1022 Salmonella cases were derived from feces and blood,identified predominantly in infants and young children under 3 years old,and frequently occurring in summer and autumn.A total of 45 serotypes were identified,and the highest detection rate was reported with Salmonella typhimurium(80.0%).Drug susceptibility test showed that Salmonella had the most high-resistance to Ampicillin(85.9%),and low-resistance to piperacillin/tazobactam,cefoperazone/sulbactam,and ciprofloxacin.The resistance rate of fecal isolates to the tested antibacterial drugs was higher than that of blood isolates.The five-year mean detection rate of multi-drug resistant Salmonella(MDR)was 8.9%,among which Salmonella typhimurium had the lowest multi-drug resistance rate(6.8%).In conclusion,antibacterials in children should be carefully selected according to the serotype and drug sensitivity results.