Foxp3和PD1在结直肠癌组织中的表达及其临床意义

Expressions and clinical significance of Foxp3 and PD1 in colorectal cancer

目的检测叉头状转录因子3(Foxp3)和程序性死亡受体1(PD1)在结直肠癌组织中的表达,探讨两者表达与患者临床病理特征及预后的关系。方法应用免疫组化(IHC)技术检测Foxp3及PD1在结直肠癌组织中和癌旁组织中的表达,Chi-square统计分析Foxp3及PD1表达强度的相关性及与患者临床病理特征,Kaplan-Meiere统计分析Foxp3及PD1表达强度和预后的关系。结果结直肠癌组织中Foxp3及PD1表达均明显高于癌旁组织中的表达,其表达分别与浸润深度、TNM分期以及淋巴结转移相关。结直肠癌组织中Foxp3表达与PD1表达呈正相关。与Foxp3阴性表达及PD1阴性表达患者相比较,Foxp3阳性表达及PD1阳性表达患者生存率低。结论结直肠癌组织中Foxp3及PD1的表达显著升高,其高表达可能促进了结直肠癌的发生发展。

Objective To study the expressions of Foxp3 and PD1 in colorectal cancer and their relationship with clinicopathological features and prognosis. Methods The expressions of Foxp3 and PD1 in colorectal cancer tissues and adjacent normal tissues were detected by immunohistochemistry. Chi-square statistically analyzed the correlation between the expression intensity of Foxp3 and PD1 and the clinicopathological characteristics of patients, and KaplanMeiere statistically analyzed the relationship between the expression intensity of Foxp3 and PD1 and prognosis. Results Compared with those in corresponding normal tissues, the expression levels of Foxp3 and PD1 were significantly higher in colorectal cancer tissues. The expression levels of Foxp3 and PD1 in colorectal cancer were significantly related to T stage,pTNM stage, and lymph node metastasis. The expression level of Foxp3 was positively related to that of PD1 in colorectal cancer tissues. Kaplan-Meier survival analyses indicated that colorectal cancer patients with higher Foxp3 or PD1 expression exhibited a shorter OS. Conclusion The elevated expressions of Foxp3 and PD1 in colorectal cancer tissues contributed to the occurrence and development of colorectal cancer.