厚朴排气合剂联合氯解磷定治疗对急性有机磷中毒患者肝功能及氧化应激水平的影响

Effect of Honpu Exhaust mixture Combined with Chlorophosphate on Liver Function and oxidative Stress in Patients with Acute organophosphorus Poisoning

目的探讨厚朴排气合剂联合氯解磷定治疗对急性有机磷中毒患者肝功能及氧化应激水平的影响。方法选取2019年1月至2020年1月在我院收治的60例急性有机磷中毒患者作为研究对象,随机分为对照组和联合组各30例,对照组给予氯解磷定治疗,联合组在对照组基础上给予厚朴排气合剂治疗。观察两组患者治疗期间机械通气时间、排出黑便时间及住院时间,对患者血清中丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)、天冬氨酸氨基转移酶(AST)、丙二醛(MDA)、人过氧化脂质(LPO)及超氧化物歧化酶(SOD)水平进行检测,统计两组患者治疗期间不良反应总发生率。结果联合组机械通气时间、排出黑便时间及住院时间均低于对照组,差异显著(P<0.05);治疗后,联合组ALT、TBiL及AST水平均低于对照组,差异显著(P<0.05);治疗后,联合组MDA、LPO水平均低于对照组,且SOD水平高于对照组,差异显著(P<0.05);两组患者不良反应总发生率无明显差异(P>0.05)。结论厚朴排气合剂联合氯解磷定治疗可以促进急性有机磷中毒患者机体及肝功能恢复,增强机体抗氧化应激能力。

Objective To investigate the effect of honpu exhaust mixture combined with phosphorous chloride on liver function and oxidative stress in patients with acute organophosphorus poisoning. Methods A total of 60 patients with acute organophosphorus poisoning admitted to our hospital from January 2019 to January 2020 were selected as the research objects, and randomly divided into the control group and the combination group, 30 cases each. The control group was treated with phosphorylated chloride, and the combination group was treated with houpu exhaust mixture on the basis of the control group. To observe the treatment time of patients in the two groups, alanine aminotransferase(ALT), total bilirubin(TBi L), aspartate aminotransferase(AST), malondialdehyde(MDA), and human lipid peroxidation in patients during treatment, as well as the length of hospital stay were affected by lung cancer. LPO and SUPERoxide dismutase(SOD) levels were detected, and the total incidence of adverse reactions during treatment was calculated. Results The mechanical ventilation time, black stool discharge time and hospital stay time in the combined group were all lower than those in the control group, and the differences were significant(P<0.05). After treatment, the levels of ALT, TBi L and AST in the combined group were significantly lower than those in the control group(P<0.05). After treatment, MDA and LPO levels in the combined group were lower than those in the control group, and SOD levels were higher than those in the control group, with significant differences(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion The treatment of honpu exhaust mixture combined with chlordiphenidine can promote the recovery of body and liver function in patients with acute organophosphorus poisoning and enhance the ability of anti-oxidative stress.