外源化合物肝毒性体外模型的研究现状和进展

Progress of in vitro models for xenobiotics hepatotoxicity evaluation

肝脏是人体最为重要的器官之一,在人体中承担着重要的消化和解毒功能。目前全球关于肝毒性的研究大多以动物为实验对象,然而随着"3R"原则——替代(Replacement)、减少(Reduction)、优化(Refinement)在研究中得到更多的实行,更多的体外毒理学模型被建立且运用到肝毒性的研究当中。此篇综述主要提供了对于一些体外肝毒性毒理学模型的简要、关键的评估,以及对未来发展方向的展望。

The liver is a vital organ, which is responsible for digestion and detoxification. Traditional studies on hepatotoxicity of xenobiotics are relied on in vivo animal models for data collection, however, animal tests are time consuming and expensive, and sometimes fail to predict human toxicity. To follow “3 R” principle(Replacement, Reduction, Refinement), more in vitro models have become more popular for the assessment of hepatotoxicity. This review presents a brief overview and comparison of some in vitro liver models, as well as prospects for future development.