Association of branched-chain amino acid intake trajectory in adulthood with the risk of type 2 diabetes and its related risk factors

To the Editor:Type 2 diabetes(T2D)showed increasing prevalence worldwide and put a huge burden on healthcare systems.[1]Branched-chain amino acids(BCAAs,including Leucine,Isoleucine,and Valine),a prominent group of essential amino acids,are important nutrition signals that have important effects on protein synthesis,glucose homeostasis,and nutrient-sensitive signaling pathways.Plasma BCAA can predict the development of T2D,whereas the studies of dietary BCAA on T2D risk showed conflicting results.[2]Most of the researches about dietary BCAAs used a single or limited number of measurements,ignoring the dynamic changes of dietary BCAA levels throughout life and their relevance to the development of diabetes.A life-course approach using multiple dietary BCAA measurements over time may shed new light on dietary BCAA trajectories and their relation to T2D risk.Therefore,in the current study,we first use latent class mixed model(LCMM)to characterize BCAA intake trajectories over 18 years in longitudinal data from China and investigate the association of BCAA intake trajectories with the risk of T2D and its biomarkers after adjusting for potential confounding factors.