静脉滴注依替米星致过敏性休克

Anaphylactic shock caused by an intravenous infusion of etimicin

1例54岁女性患者因肝血管瘤拟行腹腔镜下肝段切除术。术前30 min,给予硫酸依替米星氯化钠注射液100 mg静脉滴注预防感染。用药2 min后,患者出现全身麻木,神情淡漠,皮肤发红,冷汗和呼吸困难。呼吸22次/min,心率110次/min,血压45/32 mmHg(1 mmHg=0.133 kPa),脉搏血氧饱和度(SPO2)测不出,考虑为依替米星导致的过敏性休克。立即停用依替米星,给予吸氧、肾上腺素、甲泼尼龙琥珀酸钠、去甲肾上腺素和静脉扩充血容量等治疗。20 min后,患者症状基本缓解,呼吸18次/min,心率88次/min,血压108/60 mmHg,SPO20.99。13 h后,所有症状消失。

A 54‑year‑old female patient was scheduled to undergo laparoscopic segmental resection for hepatic hemangioma.Thirty minutes before operation,an IV infusion of etimicin sulfate and sodium chloride injection 100 mg was given to prevent infection.After 2 minutes of medication,the patient developed general numbness,apathy,redness of the skin,cold sweating,and dyspnea.Her breath rate was 22 times per minute,heart rate was 110 beats per minute,blood pressure was 45/32 mmHg,and pulse oxygen saturation(SPO2)was undetectable.Anaphylactic shock due to etimicin was considered.Etimicin was discontinued immediately and treatments such as oxygen inhalation,epinephrine,methylprednisolone sodium succinate,norepinephrine,and intravenous volume expansion were administered.Twenty minutes later,the patient′s symptoms were basically relieved,with breath rate 18 times per minute,heart rate 88 times per minute,blood pressure 108/60 mmHg,and SPO20.99.Thirteen hours later,all symptoms disappeared.