加巴喷丁致高泌乳素血症

Hyperprolactinemia caused by gabapentin

1例15岁女性患者因自身免疫性脑炎出现抽搐、精神行为异常和面部及肢体不自主运动,给予甲泼尼龙联合血浆置换和对症治疗,包括左乙拉西坦0.5 g口服、1次/12 h,苯巴比妥注射液0.1 g肌内注射、1次/6 h,氯硝西泮2 mg口服、1次/8 h,加巴喷丁胶囊0.3 g口服、1次/8 h。4 d后加巴喷丁剂量加倍;7 d后,患者月经来潮,但月经量极少;10 d后,患者出现泌乳,血清泌乳素36.69μg/L。诊断为高泌乳素血症,考虑可能与加巴喷丁有关。停用加巴喷丁,继续使用其他药物,6 d后泌乳现象消失,泌乳素15.65μg/L。次月,患者月经恢复正常。

A 15-year-old female patient with autoimmune encephalitis received methylpredniso-lone combined with plasma exchange and symptomatic treatments for convulsions,abnormal mental behavior,and involuntary facial and limb movements,including levetiracetam 0.5 g orally once per 12-hours,intramuscular injection of phenobarbital injection 0.1 g once per 6 hours,clonazepam 2-mg orally once per 8 hours,and gabapentin capsules 0.3 g orally once per 8 hours.Four days later,the dose of gabapentin was doubled;7 days later,the patient had menstruation,but the amount of menstruation was very small;10 days later,the patient developed lactation with serum prolactin 36.69-μg/L.Hyperprolactinemia was then diagnosed,which was considered to be related to gabapentin.Gabapentin was stopped and other drugs were continued.Six days later,the patient′s lactation disappeared and prolactin was 15.65-μg/L.In the following month,the patient′s menses returned to normal.