摘要
酸中毒是肿瘤微环境的标志之一,它与糖酵解、肿瘤的侵袭和转移密切相关,受多条分子通路的影响。既往结直肠肿瘤疾病的相关研究发现,酸中毒相关通路被激活是增加结直肠肿瘤细胞侵袭性的重要机制之一,同时亦可明显促进结直肠肿瘤的发生发展。靶向酸中毒治疗方式与传统治疗方式联合应用有望成为结直肠肿瘤疾病治疗的新方向。
Acidosis is one of the hallmarks of tumor microenvironment.It is closely related to glycolysis,tumor invasion and metastasis,and is affected by multiple molecular pathways.Previous studies on colorectal neoplastic diseases have found that activation of acidosis-related pathways is important mechanisms to increase the aggressiveness of colorectal tumor cells,and it can also significantly promote the occurrence and development of colorectal tumors.The combined application of targeted acidosis treatment and traditional treatment is expected to become a new direction for the treatment of colorectal tumors.
作者
王洋(综述)
李国东
汤庆超
刘明(审校)
WANG Yang;LI Guodong;TANG Qingchao;LIU Ming(Department of Colorectal Oncology Surgery,The Second Hospital of Harbin Medical University,Harbin 150081,China;Department of General Surgery,The Fourth Hospital of Harbin Medical University)
出处
《实用肿瘤学杂志》
CAS
2022年第1期74-78,共5页
Practical Oncology Journal
基金
黑龙江省自然科学基金—联合引导项目(编号:LH2020H066)。
关键词
结直肠肿瘤
酸中毒
肿瘤侵袭
治疗
Colorectal tumors
Acidosis
Tumor invasion
Treatment
