基因表达与多基因检测以及生物标志物对Luminal A型乳腺癌预后的影响

The influence of gene expression,polygene detection and biomarkers on the prognosis of Luminal A-like breast cancer

乳腺癌作为全球发病率最高的癌症,严重威胁女性的生命健康。Luminal A型乳腺癌是最常见的乳腺癌亚型,具有细胞分化程度高、侵袭力低的特点。研究发现,Luminal A型乳腺癌的腋窝淋巴结转移率仍可达到26.3%,且淋巴结转移数量越多,其5年生存率越低,所以有相当数量的Luminal A型乳腺癌患者会有较差的预后。本文主要从患者的基因表达与多基因检测以及生物标志物等方面综述影响Luminal A型乳腺癌预后的相关因素,从而为临床决策和预测患者预后提供参考资料。

Breast cancer,as the world's highest incidence of cancer,seriously threatens the life and health of women.Luminal A-like breast cancer is the most common subtype of breast cancer,with the characteristics of high degree of cell differentiation and low invasiveness.The study found that the axillary lymph node metastasis rate of Luminal A breast cancer can still reach 26.3%,and the greater the number of lymph node metastases,the lower the 5-year survival rate,so there are still a considerable number of Luminal A breast cancer patients who will have a poor the prognosis.This article mainly reviews the factors affecting the prognosis of Luminal A breast cancer from the aspects of gene expression,polygene detection and biomarkers,so as to provide reference for clinical decision-making and predicting the prognosis of patients.