肺癌患者转录辅助因子过氧化物酶增殖体激活受体γ辅助因子1、电压依赖性阴离子通道1表达及临床意义

Expressions and clinical significance of PGC1α and VDAC1 in patients with lung cancer

目的探讨肺癌患者转录辅助因子过氧化物酶增殖体激活受体γ辅助因子1(PGC1α)、电压依赖性阴离子通道1(VDAC1)表达及临床意义。方法2017年4月至2019年5月在我院就诊的肺癌患者156例(肺癌组),另收集94例肺部良性病患者(对照组),采用免疫组织化学法(SP)检测肺部组织中的PGC1α、VDAC1表达,并分析其与临床病理特征和生存预后的关系。结果肺癌组PGC1α、VDAC1的高表达率高于肺部良性疾病组(P<0.05);PGC1α、VDAC1高表达与TNM分期、淋巴结转移、远处转移呈正相关(P<0.05);生存曲线分析显示所有患者3年生存率为68.59%。PGC1α及VDAC1高表达患者3年生存率均低于低表达患者(P<0.05);肺癌组织中PGC1α表达与VDAC1表达呈正相关(P<0.05)。结论PGC1α和VDAC1在肺癌中高表达,可作为肺癌不良预后的标志物。

Objective To explore the expressions and clinical significance of peroxisome proliferator-activated receptor gamma coactivator-1α(PGC1α)and voltage-dependent anion channel 1(VDAC1)in patients with lung cancer.Methods A total of 156 patients with lung cancer were enrolled between April 2017 and May 2019 as a lung cancer group,while other 94 patients with benign lung lesion were enrolled as a control group.The expressions of PGC1αand VDAC1 in lung tissues were detected by immunohistochemistry(SP).The relationship between the expressions and the clinicopathological characteristics and survival prognosis was analyzed.Results The high expression rates of PGC1αand VDAC1 in the lung cancer group were higher than those in the control group(P<0.05).The high expressions of PGC1αand VDAC1 were positively correlated with TNM staging,lymph node metastasis,and distant metastasis.The survival curve analysis showed that the total 3-year survival rate in all patients was 68.59%.The 3-year survival rate in patients with high-expressions of PGC1αand VDAC1 was lower than that in patients with low-expressions of PGC1αand VDAC1.PGC1αexpression was significantly positively correlated with VDAC1 expression(P<0.05).Conclusion PGC1αand VDAC1 are highly expressed in lung cancer.,which can be applied as markers for poor prognosis of lung cancer.