蛋白质乙酰化修饰对自噬的调控作用

The regulatory effect of protein acetylation modification on autophagy

自噬是一种依赖于液泡或溶酶体,从酵母到人类都高度保守的物质降解途径,其在维持细胞稳态过程中起重要作用。自噬功能的异常与人类多种重大疾病如神经退行性疾病、代谢性疾病及恶性肿瘤的发生发展密切相关。作为维持生物体内稳态平衡的重要生物学过程,细胞自噬的发生受到精密的调控。乙酰化修饰作为一种可逆的蛋白翻译后修饰(post-translational modification,PTM),在自噬的精密调控中发挥重要作用。本文主要对近年来乙酰化修饰在自噬调控中的相关研究进行了综述,以期为自噬领域的基础研究提供思路,同时也为研究人员探索自噬相关疾病的预防和治疗方法提供参考。

Autophagy is a highly conserved material degradation pathway from yeast to humans that depends on vacuoles or lysosomes.It plays an important role in the maintenance of homeostasis,and its dysfunction is closely related to the pathogenesis of major diseases,such as neurodegenerative disorders,metabolic diseases,and malignant tumors.As an important biological process for the maintenance of homeostasis,autophagy is highly regulated.Acetylation of proteins is a reversible post-translational modification and plays an important role in the regulation of autophagy.In this review,we summarize research results on the modulation of acetylation in the regulation of autophagy and aim to provide insights into this biological process for the advancement of the basic research and development of preventive and therapeutic strategies against autophagy-related diseases.