表观“阅读器”BET蛋白家族对哺乳动物发育和iPSC重编程的调控

Epigenetic “reader” BET proteins regulate mammalian development and iPSC reprogramming

溴结构域和超末端结构域(bromodomain and extra-terminal,BET)蛋白家族作为表观"阅读器",在哺乳动物发育过程中起着至关重要的作用。其家族内的各成员通过识别各种表观修饰并募集相应的功能复合物,对相关基因进行精密调控,促使早期胚胎向特定方向分化和发育。另外,随着诱导性多潜能干细胞(induced pluripotent stem cell,iPSC)重编程技术发展,越来越多的研究发现BET蛋白家族在体细胞重编程中可能也占据着核心地位。本文总结了BET蛋白家族在哺乳动物发育和iPSC重编程中的作用,并对BET家族调控重编程的新机制进行了展望。

As an epigenetic “reader”,bromodomain and extra-terminal(BET) proteins play a vital role in mammalian development.Each member in the BET family regulates precisely the related genes and promotes the differentiation and development of early embryos specifically through recognizing a variety of epigenetic modifications and recruiting corresponding functional complexes.In addition,with the development of induced pluripotent stem cell(iPSC) technology,accumulating evidence have found that BET family proteins may also play a pivotal role in the iPSC reprogramming.In this review,we summarize the function of the BET family proteins in mammalian development and iPSC reprogramming from recent literatures and speculate new mechanisms of the BET family proteins in regulating reprogramming.