摘要
本文综述由间充质干细胞来源的外泌体对心肌缺血再灌注损伤的治疗作用,提示间充质干细胞来源的外泌体是一种未来可期的治疗急性心肌梗死的潜在途径。间充质干细胞来源的外泌体可以通过改善心肌细胞能量代谢、调节炎症反应、抑制细胞死亡发挥保护心肌的作用,多种非编码RNA分子在其中发挥重要作用,调整其在外泌体中的含量可以增强外泌体的治疗作用。
This paper reviews the therapeutic effect of exosomes derived from mesenchymal stem cells on myocardial ischemia-reperfusion injury,suggesting that exosomes derived from mesenchymal stem cells are a potential way to treat acute myocardial infarction in the future.Exosomes derived from mesenchymal stem cells can protect myocardium by improving energy metabolism,regulating inflammatory response and inhibiting cell death.A variety of non coding RNA molecules play an important role in exosomes.Adjusting their content in exosomes can enhance the therapeutic effect of exosomes.
作者
李一
王翔
裴作为
汪芳
LI Yi;WANG Xiang;PEI Zuo-wei;WANG Fang(The Fifth Clinical Medical School,Peking University School of Medicine,Beijing 100730,China;Institute of Geriatrics,Chinese Academy of Medical Sciences,National Geriatrics Center,Department of Cardiovascular Medicine,Beijing Hospital,Beijing 100730,China;Graduate School of Peking Union Medical College,Beijing 100730,China)
出处
《中国分子心脏病学杂志》
CAS
2021年第6期4358-4360,共3页
Molecular Cardiology of China
基金
国家重点研发计划资助(2020YFC2008100)
上海吴孟超医学科技基金会临床医学基础与应用研究专项项目(JJHXM-2019018)。
关键词
心肌缺血再灌注
外泌体
间充质干细胞
炎症反应
Myocardial ischemia reperfusion
Exosomes
Mesenchymal stem cells
Inflammatory reaction
