低分子肝素钙联合阿替普酶对急性肺栓塞患者血气指标及不良反应的影响

Effects of low molecular weight heparin calcium combined with alteplase on blood gas indexes and adverse reactions in patients with acute pulmonary embolism

目的探讨低分子肝素钙联合阿替普酶对急性肺栓塞患者血气指标及不良反应的影响。方法选取2019年2月至2020年1月本院收治的急性肺栓塞患者93例为研究对象,将入选患者随机编号1~93号,将奇数患者47例纳入对照组,将偶数患者46例纳入观察组。对照组给予阿替普酶治疗,观察组在对照组基础上增加低分子肝素钙治疗,比较两组治疗前后血气指标和不良反应情况。结果治疗后,观察组PaO;、PaCO;均高于对照组,P(A-a)O;低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义。结论低分子肝素钙联合阿替普酶联合治疗效果优于单纯使用阿替普酶治疗,更有利于改善患者血气指标,可增强治疗效果,安全性更高。

Objective To investigate the effect of low molecular weight heparin calcium combined with alteplase on blood gas indexes and adverse reactions in patients with acute pulmonary embolism.Methods 93 patients with acute pulmonary embolism admitted to our hospital from February 2019 to January 2020 were selected as the research subjects.Random numbers of the selected patients were 1-93,47 odd patients were included in the control group,and 46 even patients were included in the observation group.The control group was treated with alteplase,and the observation group added low molecular weight heparin calcium treatment on the basis of the control group.The blood gas indicators and adverse reactions before and after treatment were compared between two groups.Results After treatment,PaO;and PaCO;in the observation group were higher than those in the control group,and P(A-a)O;in the observation group was lower than that in the control group (P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The combination of low molecular weight heparin calcium and alteplase is better than the treatment with alteplase alone,and it is more conducive to improving the blood gas index of patients.It can improve the treatment effect and have higher safety.