来曲唑用于促排卵对卵泡发育及对单卵泡发育率的影响分析

Analysis of the effect of letrozole on follicle development and single follicle development rate for ovulation induction

目的研究来曲唑用于促排卵对卵泡发育及对单卵泡发育率的影响。方法选取本院2019年5月至2020年5月收治的90例因排卵障碍导致不孕的患者,按照随机数字表法分为两组,各45例。参照组采用克罗米芬治疗,实验组采用来曲唑治疗,比较两组性激素水平、临床指标、卵泡发育情况及成功妊娠率。结果用药前,两组性激素、卵泡成熟时间比较差异无统计学意义;用药后,实验组LH、T、FSH均高于参照组,E2低于参照组,子宫内膜厚度及宫颈黏液值、成熟卵泡数、成熟卵泡平均直径均高于参照组;实验组优势卵泡率(95.56%)、单卵泡排卵率(93.33%)及成功妊娠率(97.78%)均高于参照组(82.22%、77.78%及86.67%),差异有统计学意义(P<0.05)。结论来曲唑促排卵能提高排卵率、成功妊娠率,改善卵泡发育,值得临床推广应用。

Objective To study the effect of letrozole on follicle development and single follicle development rate for ovulation induction.Methods 90 patients with infertility due to ovulation disorders who were admitted to our hospital from May 2019 to May 2020 were selected and divided into two groups according to the random number table method, with 45 cases in each group. The reference group was treated with clomiphene, and the experimental group was treated with letrozole. The curative effects were compared between the two groups. Results Before treatment, there was no significant difference in sex hormones and follicle maturation time between the two groups;after treatment, the LH, T and FSH indexes of the experimental group were higher than those of the reference group, and the E2 index was low in the reference group. Endometrial thickness, cervical mucus values, the number of mature follicles and the average diameter of mature follicles in the experimental group were higher than those in the reference group;the dominant follicle rate(95.56%), single follicle ovulation rate(93.33%) and successful pregnancy rate(97.78%) in the experimental group were higher than those in the reference group(82.22%, 77.78% and 86.67%), the difference was statistically significant(P<0.05). Conclusion Letrozole can improve ovulation rate, successful pregnancy rate and follicle development, which is worthy of clinical application.