对硝基苯甲酸乙酯还原合成苯佐卡因的超声辅助工艺研究

Synthesis of Benzocaine by Ultrasonic-Assisted Reduction of p-Nitroethyl Benzoate

以对硝基苯甲酸乙酯为原料、铁粉为还原剂,采用超声辅助法合成苯佐卡因。在单因素实验的基础上,通过L_(9)(3^(3))正交实验确定苯佐卡因的最优合成条件如下:超声时间为50 min、超声功率为210 W、超声温度为70℃,在此条件下,苯佐卡因产率为55.33%。

Using p-nitroethyl benzoate as a raw material,and iron powder as a reducing agent,we synthesized Benzocaine by an ultrasonic-assisted method.On the basis of single-factor experiments,the optimal synthetic conditions of Benzocaine by L_(9)(3^(3)) orthogonal experiments can be determined as follows:the ultrasonic time of 50 min,the ultrasonic power of 210 W,and the ultrasonic temperature of 70℃.Under above conditions,the yield of Benzocaine can reach 55.33%.