碳纤维增强微孔镁掺杂羟基磷灰石生物陶瓷的制备及其性能

Preparation and properties of carbon fiber reinforced microporous magnesium doped hydroxyapatite bioceramics

生物活性多孔羟基磷灰石(HA)基陶瓷无法满足大段骨部位力学性能需求,也是骨修复材料领域亟待解决的世界性难题.本文创新性地使用不同表面改性处理碳纤维(CF)作为增强剂和造孔剂,制备兼具优良力学性能和生物学性能的微孔CF增强Mg掺杂HA(CF/Mg-HA)生物陶瓷.分别对碳纤维进行酸处理和热处理(T-CF)和采用磁控溅射法在CF表面构筑厚度可控Si涂层(Si-CF),获得造孔T-CF和增强体Si-CF;进而通过热处理和气氛保护烧结制备了具有优异力学性能和生物学性能的微孔CF/Mg-HA生物陶瓷.结果表明:微孔CF/Mg-HA(0.2 wt%T-CF+0.3 wt%Si-CF)的压缩强度比微孔Mg-HA(0.2 wt%T-CF)提高了13.5%.且由于Mg^(2+)的掺杂和微孔的共同作用,微孔CF/Mg-HA能够快速诱导磷灰石形成,具有优异的生物活性.制备的微孔CF/Mg-HA生物陶瓷在骨修复领域具有很大应用前景.

Bioactive porous HA-based ceramics can not meet the requirements of mechanical properties of large segments of bone.And it is also a worldwide problem to be solved in the field of bone repair materials.In this paper,carbon fiber(CF)with different surface modification was creatively used as reinforcer and pore-forming agent.Microporous CF-reinforced Mg-doped hydroxyapatite(CF/Mg-HA)bioceramics with excellent mechanical and biological properties was prepared.The carbon fiber was treated with acid and heat treatment(T-CF)and the thickness-controllable Si coating(Si-CF)was fabricated on the surface of CF by magnetron sputtering,respectively.The pore forming T-CF and reinforcement Si-CF were obtained.Furthermore,microporous CF/Mg-HA bioceramics with excellent mechanical and biological properties were prepared by heat treatment and atmosphere protective sintering.The results show that the compressive strength of microporous CF/Mg-HA(0.2 wt%T-CF+0.3 wt%Si-CF)is 13.5%higher than that of microporous Mg-HA(0.2 wt%T-CF).Microporous CF/Mg-HA can quickly induce the formation of apatite and has excellent biological activity due to the combined action of Mg^(2+) doping and micropore.The prepared microporous CF/Mg-HA bioceramic has a great application prospect in the field of bone repair.