低分子量肝素对子痫前期产妇产后凝血指标的影响

The Effect of a Low Molecular Weight Heparin on Postpartum Coagulation Parameters in Women with Preeclampsia

目的探讨低分子量肝素在子痫前期患者中的应用效果。方法回顾性调查我院2019年1~4月290例子痫前期患者,根据产后1 d采用的治疗方法分为肝素组(190例)及对照组(100例),分析比较两组的一般资料和凝血指标差异。结果肝素组的新生儿体重和Apgar评分(1 min)低于对照组(P<0.05)。肝素组与对照组在产前仅凝血酶时间、D-二聚体、血小板体积分布宽度有差异,产后1 d肝素组纤维蛋白原含量、血小板计数、血小板压积低于对照组,凝血酶时间、D-二聚体、血小板体积分布宽度高于对照组(P<0.05)。产后3 d仅D-二聚体有差异。结论在产后1 d应用低分子量肝素有助于子痫前期患者产后凝血状态向正常恢复。

Objective To investigate the effect of a low molecular weight heparin in the treatment of patients with preeclampsia.Methods A retrospective investigation for 290 preeclampsia patients in our hospital was conducted from January to April 2019.These patients were divided into heparin group(190 cases)and control group(100 cases)based on treatment method adopted at the first day postpartum.The differences in general data and blood coagulation parameters between two groups were analyzed.Results Neonatal weight and Apgar score(1 min)in heparin group were lower than those in control group(P<0.05).In levels of coagulation parameters,only thrombin time,D-dimer and platelet distribution width were different between heparin group and control group before delivery.On postpartum day 1,fibrinogen,platelet count and plateletcrit in heparin group were lower than those in control group,while thrombin time,D-dimer and platelet distribution width were higher(P<0.05).On postpartum day 3,only D-dimer was different between two groups.Conclusion Low molecular weight heparin used on postpartum day 1 can help patients with preeclampsia to return to normal postpartum coagulation parameters.