摘要
微生物混合感染性角膜炎是一种因角膜感染,严重时会致盲的眼表疾病,起病急、发展迅速,严重时会引起角膜穿孔,可致视力下降或视力丧失。建立微生物混合感染性角膜炎动物模型有利于探索其发病机制、预防、临床诊断和治疗等。本文对微生物混合感染性角膜炎动物模型的制作方法及造模感染成功后的鉴定方法进行综述,旨在为进一步开发、研究该病的动物模型提供参考。
Microbial mixed infectious keratitis is an ocular surface disease caused by corneal infection,which has an acute onset and rapid progression and can lead to blindness in severe cases.Establishing an animal model of microbial mixed infectious keratitis is conducive to exploring its pathogenesis,prevention,clinical diagnosis and treatment.This article reviews the methods of making animal models of mixed infectious keratitis with microorganisms and the diagnostic methods after successful modelling infections,aiming to provide references for the further development and research of animal models of the disease.
作者
李玉婷
李妍
王岚
胡竹林
Yu-Ting Li;Yan Li;Lan Wang;Zhu-Lin Hu(Department of Ophthalmology, Affiliated Hospital of Yunnan University, Department of Ophthalmology, the Second People's Hospital of Yunnan Province, Yunnan Eye Hospital, Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University, Yunnan Eye Institute, Yunnan Clinical Medical Research Center of Eye Diseases, Yunnan Clinical Medical Center of Eye Diseases, Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology, Kunming 650021, Yunnan Province, China)
出处
《国际眼科杂志》
CAS
北大核心
2022年第2期230-234,共5页
International Eye Science
基金
云南省基础研究计划(昆医联合专项)[No.202001AY070001(-165)]。
