早期适时肠内营养干预对重症胰腺炎患者机体营养状况及免疫功能的影响

Effects of early and timely enteral nutrition intervention on nutritional status and immune function of patients with severe pancreatitis

目的探讨早期适时肠内营养干预对重症胰腺炎患者机体营养状况及免疫功能的影响。方法选择2020年1月—2021年1月医院收治的重症胰腺炎患者60例,按照组间基本特征具有可比性的原则分为对照组与观察组,每组30例。对照组予以延迟肠内营养干预,观察组予以早期适时肠内营养干预,护理干预14 d后比较两组患者的机体营养状况、免疫功能、肠黏膜功能及康复指标。结果观察组干预后的机体血红蛋白(Hb)、前白蛋白(PA)、白蛋白(ALB)、转铁蛋白(TRF)及总蛋白(TP)水平均高于对照组(P<0.05);观察组血清CD3^(+)、CD4^(+)、免疫球蛋白A(IgA)及免疫球蛋白G(IgG)水平均高于对照组(P<0.05);观察组的D-乳酸(DLA)低于对照组(P<0.05);观察组干预后腹胀、腹痛、发热症状消失时间及肠鸣音、尿淀粉酶、血淀粉酶恢复至正常水平的时间均短于对照组(P<0.05)。结论早期适时肠内营养干预用于重症胰腺炎患者效果显著,有助于改善机体营养状况及免疫功能,促进肠黏膜功能恢复,提升康复质量。

Objective To investigate the eff ects of early and timely enteral nutrition intervention on nutritional status and immune function of patients with severe pancreatitis.Methods 60 patients with severe pancreatitis admitted in the hospital from January 2020 to January 2021 were selected and divided into control group and observation group according to the principle of comparability of basic characteristics between groups,with 30 cases in each group.The control group was given postponed enteral nutrition intervention and the observation group was given early and timely enteral nutrition intervention.After 14 days of nursing intervention,the body nutritional status,immune function,intestinal mucosal function and rehabilitation indicators of the two groups were compared.Results After intervention,the levels of hemoglobin(Hb),prealbumin(PA),albumin(ALB),transferrin(TRF)and total protein(TP)in observation group were higher than the control group(P<0.05).The serum levels of CD3^(+),CD4^(+),immunoglobulin A(IgA)and immunoglobulin G(IgG)in observation group were higher than the control group(P<0.05).The D-lactic acid(DLA)in observation group was lower than the control group(P<0.05).After intervention,the symptoms of abdominal distention,abdominal pain and fever disappeared time and the time of intestinal sound,urinary amylase and blood amylase returning to the normal level in the observation group was shorter than the control group(P<0.05).Conclusion Early and timely enteral nutrition intervention was eff ective in patients with severe pancreatitis,which improve the nutritional status and immune function of the body,promote the recovery of intestinal mucosa function and improve the quality of rehabilitation.