有机室温磷光材料在生物医学中的应用

Organic Room Temperature Phosphorescent Materials for Biomedical Applications

近年来,纯有机室温磷光(RTP)材料由于具有长的激发态寿命、大的Stokes位移、丰富的激发态性质等特点而备受研究者的广泛关注。相较于重金属配合物或无机磷光材料,有机磷光材料的原料来源广、成本低、合成条件温和,兼具质轻、柔性、可大面积制备等诸多优势,室温磷光材料在数据加密、传感、有机电致发光、生物成像等领域展现出良好的应用前景。有机磷光材料具有长寿命发光和三线态发射的特征,利用时间分辨技术能有效扣除生物组织自身的背景荧光干扰,极大地提高生物传感和成像的灵敏度与信噪比,并通过与三线态氧气的TTA过程,有望实现这类材料在光动力抗癌与抗菌等生物领域的应用。而且纯有机磷光材料不存在重金属元素的毒性问题。因此,纯有机磷光材料在生物成像、癌症治疗等生物领域实现很好的应用。本文总结了近年来有机室温磷光在生物应用中的研究进展,包括生物成像、生物传感、光动力抗癌、抗菌等。最后,提出该领域尚待解决的问题并展望未来前景。

In recent years,pure organic room temperature phosphorescent(RTP)materials have received extensive attention from researchers due to their long-excited state lifetime,large Stokes shift,and rich excited state properties.Compared with heavy metal complexes or inorganic phosphorescent materials,organic phosphorescent materials have a wide range of raw materials,low cost,mild synthesis conditions,light weight,flexibility,large area preparation,and many other advantages.Thus,RTP materials show great potential in the field of data encryption,sensing,organic electroluminescence,biological imaging and others.Organic phosphorescent materials have the characteristics of long-lived luminescence and triplet emission.The use of time-resolved technology can effectively eliminate the background fluorescence interference of biological tissues,which greatly improves the sensitivity and signal-to-noise ratio of biosensing and imaging.And through the TTA process with triplet oxygen,it is expected to realize the application of such materials in biological fields such as photodynamic anticancer and antibacterial.Moreover,pure organic phosphorescent materials do not have the toxicity from heavy metals.Therefore,pure organic phosphorescent materials have achieved good applications in biological fields such as biological imaging and cancer treatment.In this review,we summarized the research progress of organic room temperature phosphorescence in biological applications,including bioimaging,biosensing,photodynamic anticancer,antibacterial,etc.Finally,we propose the problems and outlook in this field.