不同治疗方案在急性心肌梗死患者中的应用研究

Application of different treatment schemes in patients with acutemyocardial infarction

目的探讨不同治疗方案在急性心肌梗死患者中的治疗效果。方法回顾性选取2015年8月至2020年8月于山东省聊城市中医医院治疗的急性心肌梗死患者65例作为研究对象。依据治疗方法不同进行分组,采用静脉溶栓及常规西医治疗的患者32例作为对照组,在对照组治疗基础上加用活血化瘀中药注射剂治疗的33例患者作为研究组。比较治疗前后两组心功能以及主要心脏不良事件的发生情况。结果治疗前后,各组内左心室射血分数(LVEF)、N末端B型利尿钠肽原(NT-proBNP)及6 min步行试验(6MWT)比较,差异有统计学意义(P<0.05);治疗前,组间LVEF,NT-proBNP及6MWT差异无统计学意义(P>0.05),治疗后,研究组各项指标均优于对照组,差异有统计学意义(P<0.05)。研究组主要心脏不良事件总发生率为6.06%,低于对照组的25.00%,组间差异有统计学意义(P<0.05)。结论针对急性心肌梗死患者实施静脉溶栓加用活血化瘀中药注射剂治疗,两者之间相互结合,能够恢复心肌血流,促进心功能的恢复,且可明显降低患者治疗后的主要心脏不良事件发生。

Objective To explore the therapeutic effect of different treatment schemes in patients with acute myocardial infarction.Methods A total of 65 patients with acute myocardial infarction treated in Liaocheng Hospital of traditional Chinese Medicine from August 2015 to August 2020 were retrospectively selected as the research objects.According to the different treatment methods,32 patients treated with intravenous thrombolysis and conventional western medicine were used as the control group,and on the basis of the control group,33 patients treated with traditional Chinese medicine injection for promoting blood circulation and removing blood stasis were used as the study group.The cardiac function and the occurrence of major cardiac adverse events of the two groups before and after treatment were compared.Results The differences of left ventricular ejection fraction(LVEF),N terminal pro B type natriuretic peptide(NT-proBNP)and 6-minute walk test(6MWT)in each group before and after treatment were statistically significant(P<0.05);Before treatment,there was no significant difference in LVEF,NT proBNP and 6MWT between groups(P>0.05),after treatment,the indexes in the study group were better than those in the control group,the difference was statistically significant(P<0.05).The total incidence of the occurrence of major cardiac adverse events in the study group was 6.06%,which was lower than 25.00%in the control group(P<0.05).Conclusion Intravenous thrombolytic therapy combined with traditional Chinese medicine injection for promoting blood circulation and removing blood stasis for patients with acute myocardial infarction can restore myocardial blood flow,promote the recovery of cardiac function,which can significantly reduce the occurrence of major cardiac adverse events after treatment.