摘要
The pandemic of coronavirus disease 2019(COVID-19)has already evoked massive influence.The global pandemic has been ravaging the whole world for a year,with the number of confirmed human infection cases over 150 million and a death toll exceeding 3 million.Although the genomic sequence of the cognate pathogen SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has been quickly determined,there are still many unknown aspects,including the virus origin and evolution trend,and the effectiveness of current vaccines and drugs against the mutating virus.This review summarizes current knowledge and advances about COVID-19,including virus origin,transmission and infection,with the aim to improve the understanding of COVID-19 and provide a new perspective for future studies.
基金
supported by the Strategic Priority Research Program of CAS(XDB29010000)
the National Science and Technology Major Project(2018ZX10101004)
National Key Research and Development Program of China(2020YFC0845900)
the National Natural Science Foundation of China(NSFC)(82041016,81871658 and 81802010)
a grant from the Bill&Melinda Gates Foundation
is partially supported by the Yanqi Lake Meeting organized by the Academic Divisions of CAS
R.P.is supported by the Young Elite Scientist Sponsorship Program(YESS)by China Association for Science and Technology(CAST)(2018QNRC001)
Y.S.is also supported by the Youth Innovation Promotion Association of CAS.
