肿瘤异常糖链糖蛋白在肾癌中的诊断价值

Tumor abnormal protein for the diagnosis of renal cell carcinoma

目的:研究外周血肿瘤异常糖链糖蛋白(tumor abnormal protein,TAP)的表达对早期肾癌的诊断价值。方法:对45例肾癌患者(肾癌组)、32例肾脏良性病变患者(肾良性病变组)和42例体检健康人群(正常组)的外周血TAP值进行分析;绘制受试者工作特征(receiver operating characteristics,ROC)曲线评估TAP对肾癌的诊断效能;分析肾癌组中TAP阳性表达与患者临床病理特征的关系。结果:肾癌组中外周血TAP水平明显高于肾良性病变组和正常组。通过评估TAP对肾癌的诊断效能,发现TAP诊断肾癌的ROC曲线下面积为0.92(95%CI:0.82~0.95),其诊断肾癌的灵敏度和特异度分别为73%和91%。结论:肾癌患者外周血中TAP呈高表达,可作为肾癌早期诊断的肿瘤标志物。

Objective:To study the value of tumor abnormal protein(TAP)expression in peripheral blood for diagnosis of early renal cell carcinoma.Methods:TAP expression was analyzed in the peripheral blood of 45 patients with renal cell carcinoma(carcinoma group),32 patients with benign renal lesions(benign group)and 42 healthy people(normal group).The receiver operating characteristics(ROC)curve was used to evaluate the diagnostic efficacy of TAP detection for renal cell carcinoma.An analysis of the relationship between TAP expression and the clinicopathological features in renal cell carcinoma was performed.Results:TAP levels were significantly higher in carcinoma group patients than that in benign group and normal group.To evaluate the diagnostic efficacy of TAP for renal cell carcinoma,the area under the ROC curve was 0.92(95%CI:0.82~0.95),and the sensitivity and specificity in the diagnosis of renal cell carcinoma was 73%and 91%,respectively.Conclusion:The expression of TAP in peripheral blood of patients with renal cell carcinoma was significantly higher than that in nonneoplastic patients,which can be a tumor marker for early diagnosis of renal cell carcinoma.