巴中地区女性体检人群HPV病毒感染情况及对宫颈病变发生率的影响

Infection of HPV virus and its influence on incidence of cervical lesions in female physical examination population in Bazhong area

目的:了解四川省巴中地区女性人乳头瘤病毒(human papillomavirus,HPV)感染情况,分析其型别与宫颈病变的相关性。方法:收集2015年01月至2019年06月在我院进行健康体检的5046例女性作为研究对象,采用荧光定量PCR法对15种高危HPV基因亚型进行检测,分析是否发生HPV感染及不同HPV亚型对宫颈鳞状上皮内病变的影响。结果:HPV感染率为24.36%(1229/5046)。单一HPV感染954例,占全部感染的77.62%,感染率为18.91%;多重HPV感染275例,占全部感染的22.38%,感染率为5.45%。感染率前5位的HPV亚型分别为HPV16(3.86%,195例)、HPV18(3.63%,183例)、HPV52(2.26%,114例)、HPV58(1.61%,81例)、HPV51(1.41%,71例)。≤30岁、31~40岁、41~50岁、>50岁四个年龄组HPV阳性感染率分别为30.28%、22.89%、25.31%、20.00%,各年龄组感染率之间差异有统计学意义(P<0.001)。多重感染患者的高度鳞状上皮内病变的非典型鳞状上皮细胞(ASC-H)、低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)和鳞状细胞癌(SCC)四种宫颈鳞状上皮内病变的发生比例高于单一感染患者,但差异尚未显示有统计学意义(P=0.608)。结论:巴中地区女性体检人群HPV感染率较高,应加强和普及本地区HPV筛查工作。

Objective:To investigate the infection of human papillomavirus(HPV)in women in Bazhong area of Sichuan province,and to analyze the correlation between HPV types and cervical lesions.Methods:A total of 5046 women who underwent health examination in our hospital from January 2015 to June 2019 were selected as subjects.Fifteen high-risk HPV genotypes were detected by fluorescence quantitative PCR.The effects of HPV infection and different HPV subtypes on cervical squamous intraepithelial lesions were analyzed.Results:The infection rate of HPV was 24.36%(1229/5046).There were 954 cases of single HPV infection,accounting for 77.62%of all infections,and the infection rate was 18.91%.There were 275 cases of multiple HPV infection,accounting for 22.38%of all infections,and the infection rate was 5.45%.The top five HPV subtypes were HPV16(3.86%,195 cases),HPV18(3.63%,183 cases),HPV52(2.26%,114 cases),HPV58(1.61%,81 cases),HPV51(1.41%,71 cases),respectively.The positive rates of HPV infection were 30.28%,22.89%,25.31%and 20.00%in the four age groups(≤30 years old,31~40 years old,41~50 years old,>50 years old),respectively.There was significant difference among the four age groups(P<0.001).The incidence of atypical squamous epithelial cells with high-grade squamous intraepithelial lesions(ASC-H),low-grade squamous intraepithelial lesions(LSIL),high-grade squamous intraepithelial lesions(HSIL)and squamous cell carcinoma(SCC)in patients with multiple infection was higher than that in patients with single infection,but the difference was not statistically significant(P=0.608).Conclusion:The infection rate of HPV in female physical examination population is higher in Bazhong area,so the screening of HPV should be strengthened and popularized.