轻微性肝性脑病的诊断进展

Progress in the diagnosis of minimal hepatic encephalopathy

肝性脑病(HE)是肝硬化常见的严重并发症。一旦发生肝性脑病,提示慢性肝病患者预后不佳。轻微性肝性脑病(MHE)是HE的早期阶段,无明显症状,但在神经心理学和/或神经生理学测试中表现出异常的结果。MHE影响患者的生活质量、就业及驾驶能力并具有进展到显性肝性脑病的高风险。应探讨诊断MHE的各种方法,加强临床医生在日常诊疗活动中对MHE的重视并对肝硬化患者进行有效的MHE筛查。

Hepatic encephalopathy(HE)is a common serious complication of、liver cirrhosis,with sudden onset,indicating a poor prognosis in patients with chronic liver disease.Minimal hepatic encephalopathy(MHE)is an early stage of HE with no apparent symptoms,but it shows abnonnal results in neuropsychological and/or neurophysiological tests.MHE af Tects patients'quality of life,employability,driving ability,and has a high risk of developing overt hepatic encephalopathy(OHE).This article aims to explore various diagnostic methods,strengthen the routine work of clinicians in diagnosis and treatment,and develop an effective MHE screening protocol.