甲泼尼龙琥珀酸钠治疗儿童重症支原体肺炎的疗效及对炎症因子的影响

Effect of methylprednisolone sodium succinate in the treatment of severe mycoplasma pneumonia in children and its effects on inflammatory factors

目的:探讨甲泼尼龙琥珀酸钠对比常规对症治疗儿童重症支原体肺炎的疗效及对炎性因子的影响。方法:选择重症支原体肺炎患儿60例,采用随机数字表法将病人分为研究组与对照组,各30例。对照组采用常规对症治疗,研究组在对照组基础上结合甲泼尼龙琥珀酸钠治疗。比较2组临床症状改善情况,治疗前后血清中白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)及C反应蛋白(CRP)水平。结果:观察组患儿退热时间、咳嗽消失时间、肺部啰音消失时间均明显短于对照组(P<0.01)。治疗前2组患儿CRP、IL-6、TNF-α、IFN-γ水平差异均无统计学意义(P>0.05);治疗后2组患儿CRP、IL-6、TNF-α、IFN-γ水平均低于治疗前(P<0.05),且研究组患儿CRP、IL-6、TNF-α、IFN-γ水平均低于对照组(P<0.05~P<0.01)。结论:在常规对症治疗基础上给予甲泼尼龙琥珀酸钠辅助治疗,可有效改善重症支原体肺炎患儿的临床症状,促进炎性因子及CRP水平下降,降低炎症反应,疗效显著。

Objective:To investigate the effects of methylprednisolone sodium succinate in the treatment of severe mycoplasma pneumonia,and its influence on inflammatory factors in children.Methods:Sixty children with severe mycoplasma pneumonia were divided into the study group and control group according to the random umber table method(50 cases in each group).The control group was treated with conventional symptomatic treatment,while the study group was treated with methylprednisolone sodium succinate on the basis of the control group.The clinical symptoms improvement,and serum levels of interleukin-6(IL-6),tumor necrosis factorα(TNF-α),interferonγ(IFN-γ)and C-reactive protein(CRP)before and after treatment were compared between two groups.Results:The time of fever abatement,cough disappearance and lung rales disappearance in study group were significantly shorter than those in control group(P<0.01).Before treatment,there was no statistical significance in the levels of CRP,IL-6,TNF-αand IFN-γbetween two groups(P>0.05).After treatment,the levels of CRP,IL-6,TNF-αand IFN-γin two groups were lower than those before treatment(P<0.05),and the levels of CRP,IL-6,TNF-αand IFN-γin study group were lower than those in control group(P<0.05 to P<0.01).Conclusions:On the basis of routine symptomatic treatment,the adjuvant therapy of methylprednisolone sodium succinate can effectively improve the clinical symptoms,promote the decline of inflammatory factors,reduce the inflammatory response,and has significant effects in children with severe mycoplasma pneumonia.