老年人衰弱和射血分数保留性心力衰竭病理生理学机制的研究进展

Pathophysiological Mechanisms of Frailty and Heart Failure with Preserved Ejection Fraction in the Elderly

衰弱和射血分数保留性心力衰竭是具有密切关联的疾病,二者具有共通的病理生理学机制,如慢性炎症、氧化应激、内分泌代谢和神经激素调节异常等,通过上述多种潜在机制的相互作用加速了二者的疾病进程,从而共同导致老年患者的不良预后。目前针对衰弱及射血分数保留性心力衰竭的干预方式有限,尤其是药物治疗尚存在局限性,深入认识衰弱和射血分数保留性心力衰竭的病理生理学机制有助于探索二者潜在的治疗靶点,以期改善老年患者的预后。

Frailty and heart failure with preserved ejection fraction(HFpEF)are closely related diseases that share common pathophysiological mechanisms,such as chronic inflammation,oxidative stress,abnormal endocrine metabolism and neurohormonal regulation,which interact with each other to accelerate the disease process and lead to the poor prognosis in elderly patients.The current interventions for frailty and HFpEF are limited,especially in terms of pharmacological treatment.An in-depth understanding of the pathophysiological mechanisms of frailty and HFpEF will help to explore potential therapeutic targets in order to improve the prognosis of elderly patients.